Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMGW1ID)

Drug Name
Sirolimus Drug Info
Synonyms
53123-88-9; Rapamune; Rapamycin (Sirolimus); AY-22989; Rapammune; sirolimusum; WY-090217; RAPA; Antibiotic AY 22989; AY 22989; UNII-W36ZG6FT64; CCRIS 9024; CHEBI:9168; SILA 9268A; W36ZG6FT64; HSDB 7284; C51H79NO13; NSC 226080; DE-109; NCGC00021305-05; DSSTox_CID_3582; DSSTox_RID_77091; DSSTox_GSID_23582; Cypher; Supralimus; Wy 090217; Perceiva; RAP; RPM; Rapamycin from Streptomyces hygroscopicus; SIIA 9268A; LCP-Siro; MS-R001; Rapamune (TN); Rapamycin (TN); Sirolimus (RAPAMUNE); Rapamycin C-7, analog 4; Sirolimus (USAN/INN); Sirolimus [USAN:BAN:INN]; Sirolimus, Rapamune,Rapamycin; Heptadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy; 23,27-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine; 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine; 23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29; 3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone; Sirolimus (MTOR inhibitor)
Therapeutic ClassImmunosuppressive Agents
Cross-matching ID
PubChem CID
5284616
ChEBI ID
CHEMBL413
CAS Number
CAS 53123-88-9
TTD Drug ID
D03LJR
VARIDT Drug ID
DR00262
INTEDE Drug ID
DR1489
ACDINA Drug ID
D00627

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
ECM-receptor interaction 2.31 0.00e+0 80/88 (90.91%) HMMR;ITGB5;THBS1;...
Sulfur metabolism 1.83 3.01e-2 9/10 (90%) PAPSS2;TST;MPST;...
Fatty acid biosynthesis -1.63 4.51e-2 16/18 (88.89%) ACSL1;OXSM;MCAT;...
Glycine, serine and threonine metabolism -1.72 2.05e-2 31/40 (77.5%) SHMT1;GCAT;ALAS1;...
Arginine and proline metabolism -1.72 2.12e-2 39/50 (78%) GOT2;ALDH18A1;GOT1;...
IL-17 signaling pathway -1.72 2.20e-2 84/94 (89.36%) CASP3;MAPK9;IL17A;...
Fructose and mannose metabolism -1.73 2.37e-2 30/33 (90.91%) TPI1;AKR1B10;PFKFB2;...
Citrate cycle (TCA cycle) -1.74 2.49e-2 30/30 (100%) IDH3B;ACO1;DLD;...
Terpenoid backbone biosynthesis -1.78 1.81e-2 18/22 (81.82%) ICMT;HMGCS2;PCYOX1;...
RNA polymerase -1.81 1.49e-2 23/31 (74.19%) POLR3F;POLR2B;POLR2C;...
Spinocerebellar ataxia -1.85 8.85e-3 128/143 (89.51%) NFYA;PIK3CB;AFG3L2;...
Cysteine and methionine metabolism -1.85 9.96e-3 43/50 (86%) AHCYL2;LDHA;GCLC;...
PPAR signaling pathway -1.86 1.14e-2 66/74 (89.19%) ACADL;LPL;ACSL1;...
RNA transport -1.90 8.30e-3 128/186 (68.82%) PNN;NUP153;NUP188;...
Biosynthesis of unsaturated fatty acids -1.98 1.99e-3 21/27 (77.78%) ACAA1;ACOX1;FADS1;...
Spliceosome -2.11 0.00e+0 101/150 (67.33%) SNRNP40;THOC2;SF3B2;...
Steroid biosynthesis -2.23 0.00e+0 19/20 (95%) CYP51A1;LSS;SC5D;...
Proteasome -2.27 0.00e+0 44/46 (95.65%) IFNG;PSMB8;PSMC1;...
Ribosome biogenesis in eukaryotes -2.46 0.00e+0 52/108 (48.15%) SNU13;NOP10;NMD3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 10uM - 12uM 6H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 20uM 6H, 24H, 48H
Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
K-562 CVCL_0004 Homo sapiens 0.01uM - 10uM 4H, 24H
Multiple myeloma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
KMS-34 CVCL_1333 Homo sapiens 0.01uM - 10uM 24H
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.002uM - 20uM 3H, 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Breast carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-20 CVCL_0178 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Hs 578T CVCL_0332 Homo sapiens 0.04uM - 10uM 3H, 6H, 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 3H, 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H, 48H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colon carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 TP53(-/-) CVCL_HD97 Homo sapiens 0.04uM - 10uM 24H
HCT 116 CVCL_0291 Homo sapiens 0.04uM - 10uM 24H
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 10uM - 12uM 6H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 20uM 2H, 6H, 24H
LoVo CVCL_0399 Homo sapiens 10uM - 12uM 6H
MDST8 CVCL_1400 Homo sapiens 10uM - 12uM 6H
NCI-H508 CVCL_1561 Homo sapiens 10uM - 12uM 6H
SNU-1040 CVCL_5001 Homo sapiens 10uM - 12uM 6H
SNU-C4 CVCL_5008 Homo sapiens 10uM - 12uM 6H
SNU-C5 CVCL_5009 Homo sapiens 10uM - 12uM 6H
SW480 CVCL_0546 Homo sapiens 10uM - 12uM 6H
SW620 CVCL_0547 Homo sapiens 10uM - 12uM 6H
SW948 CVCL_0550 Homo sapiens 10uM - 12uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 10uM - 12uM 6H
HCT 116 (Parent) CVCL_0291 Homo sapiens 0.04uM - 10uM 24H
HT115 CVCL_1294 Homo sapiens 10uM - 12uM 6H
RKO CVCL_0504 Homo sapiens 10uM - 12uM 6H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUES 3 CVCL_B062 Homo sapiens 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 10uM - 12uM 6H
SNG-M CVCL_1707 Homo sapiens 10uM - 12uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 10uM - 12uM 6H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 20uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 20uM 6H, 24H, 48H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 3.33uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.002uM - 20uM 6H, 24H, 48H
A549/Asc-1 CVCL_YA87 Homo sapiens 10uM 24H
DV-90 CVCL_1184 Homo sapiens 10uM - 12uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 10uM - 12uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 10uM - 12uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 10uM - 12uM 6H
T3M-10 CVCL_1729 Homo sapiens 10uM - 12uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 10uM - 12uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 10uM - 12uM 6H
HCC515 CVCL_5134 Homo sapiens 0.002uM - 20uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 10uM - 12uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 10uM - 12uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 10uM - 12uM 6H
Lymph node
Burkitt lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BJAB CVCL_5711 Homo sapiens 0.01uM - 10uM 3H, 4H, 6H, 24H
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HBL-1 CVCL_4213 Homo sapiens 0.01uM - 10uM 4H, 24H
OCI-Ly10 CVCL_8795 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly19 CVCL_8797 Homo sapiens 0.01uM - 10uM 4H, 24H
OCI-Ly3 CVCL_8796 Homo sapiens 0.01uM - 10uM 4H, 24H
TMD8 CVCL_A440 Homo sapiens 0.01uM - 10uM 3H, 4H, 6H, 24H
WSU-DLCL2 CVCL_1787 Homo sapiens 10uM - 12uM 6H
Mantle cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MINO CVCL_4965 Homo sapiens 0.01uM - 10uM 3H, 6H, 24H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 10uM - 12uM 6H
OV7 CVCL_1623 Homo sapiens 10uM - 12uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 10uM - 12uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 10uM - 12uM 6H
RMUG-S CVCL_1666 Homo sapiens 10uM - 12uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 10uM - 12uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 6H, 24H
Peripheral blood
Acute B-lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NALM-6 CVCL_0092 Homo sapiens 0.01uM - 10uM 24H
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 12uM 3H, 4H, 6H, 24H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HL-60 CVCL_0002 Homo sapiens 0.08uM - 10uM 2H, 24H
NOMO-1 CVCL_1609 Homo sapiens 10uM - 12uM 6H
PL-21 CVCL_2161 Homo sapiens 10uM - 12uM 6H
SKM-1 CVCL_0010 Homo sapiens 10uM - 12uM 6H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 10uM - 12uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
LNCaP CVCL_0395 Homo sapiens 0.04uM - 10uM 3H, 24H
PC-3 CVCL_0035 Homo sapiens 0.002uM - 20uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 1.11uM - 20uM 6H, 24H, 48H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 20uM 6H, 24H
SK-L CVCL_1699 Homo sapiens 10uM 24H
SK-MEL-1 CVCL_0523 Homo sapiens 10uM - 12uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 10uM - 12uM 6H
SK-MEL-5 CVCL_0527 Homo sapiens 0.01uM - 10uM 24H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 10uM - 12uM 6H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H