Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMGXENV)

Drug Name
Saxagliptin Drug Info
Synonyms
Onglyza; BMS 477118-11; BMS-477118; Kombiglyze XR (TN); OPC-262; Onglyza (TN); BMS-477118-11; (1S,5S)-2-[2-amino-2-(3-hydroxy-1-adamantyl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile; 2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2S)-amino(3-hydroxytricyclo[3.3
Cross-matching ID
PubChem CID
11243969
ChEBI ID
CHEMBL385517
CAS Number
CAS 361442-04-8
TTD Drug ID
D0K9MY
VARIDT Drug ID
DR00226
INTEDE Drug ID
DR1465
ACDINA Drug ID
D00616

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome biogenesis in eukaryotes 2.30 0.00e+0 52/108 (48.15%) NVL;IMP4;NOP56;...
DNA replication 2.27 0.00e+0 34/36 (94.44%) FEN1;PCNA;DNA2;...
Cell cycle 2.03 0.00e+0 110/124 (88.71%) CDC25A;CDC45;PLK1;...
Spliceosome 1.93 0.00e+0 101/150 (67.33%) PRPF4;HSPA1A;SRSF7;...
Fanconi anemia pathway 1.82 1.59e-2 36/54 (66.67%) FANCI;REV1;RAD51;...
Regulation of lipolysis in adipocytes 1.75 3.31e-2 52/55 (94.55%) ADCY9;NPY1R;PLAAT3;...
Citrate cycle (TCA cycle) 1.75 2.84e-2 30/30 (100%) IDH3A;SDHA;FH;...
Base excision repair 1.74 2.58e-2 29/33 (87.88%) FEN1;PCNA;PARP1;...
Oocyte meiosis 1.68 3.62e-2 90/129 (69.77%) ADCY9;IGF1;PLK1;...
Aminoacyl-tRNA biosynthesis 1.67 3.42e-2 15/66 (22.73%) IARS2;FARSA;NARS2;...
RNA transport 1.67 3.32e-2 128/186 (68.82%) ELAC2;NCBP1;EIF4G1;...
Progesterone-mediated oocyte maturation 1.64 4.24e-2 75/100 (75%) ADCY9;CDC25A;IGF1;...
Non-homologous end-joining 1.63 4.40e-2 11/13 (84.62%) FEN1;PRKDC;DCLRE1C;...
Salmonella infection -1.70 4.81e-2 198/249 (79.52%) MYL5;TRADD;NLRP3;...
Fluid shear stress and atherosclerosis -1.74 3.34e-2 123/139 (88.49%) JUN;PLAT;MAPK14;...
Type I diabetes mellitus -1.75 2.56e-2 38/43 (88.37%) HLA-E;CD80;HLA-A;...
Necroptosis -1.75 2.88e-2 113/159 (71.07%) GLUD2;TICAM1;CHMP2B;...
Neutrophil extracellular trap formation -1.76 2.80e-2 101/189 (53.44%) MAP2K2;HAT1;FPR2;...
Pathogenic Escherichia coli infection -1.78 2.49e-2 152/197 (77.16%) IL18;CASP8;CLDN5;...
Complement and coagulation cascades -1.81 1.84e-2 76/85 (89.41%) FGA;C2;PLAT;...
Steroid biosynthesis -1.81 2.30e-2 19/20 (95%) CYP24A1;DHCR24;LIPA;...
Graft-versus-host disease -1.86 2.30e-2 32/42 (76.19%) HLA-E;CD80;HLA-A;...
Bacterial invasion of epithelial cells -1.92 2.30e-2 59/77 (76.62%) PTK2;ACTB;ARPC2;...
Mineral absorption -2.05 0.00e+0 48/60 (80%) TF;ATP2B4;ATOX1;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H