Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMGYBZI)

Drug Name
PHA-739358 Drug Info
Synonyms Danusertib; PHA 739358; Danusertib, PHA-739358; (R)-N-(5-(2-methoxy-2-phenylacetyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-4-(4-methylpiperazin-1-yl)benzamide; 5-Amido-pyrrolopyrazole 9d
Cross-matching ID
PubChem CID
11442891
ChEBI ID
CHEMBL94490
CAS Number
CAS 827318-97-8
TTD Drug ID
D02RJY

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
ABC transporters 1.92 2.12e-2 37/45 (82.22%) TAP1;ABCC3;ABCG1;...
Regulation of lipolysis in adipocytes 1.86 3.70e-2 52/55 (94.55%) FABP4;CGA;PIK3R3;...
Phosphatidylinositol signaling system 1.85 2.47e-2 82/97 (84.54%) PIK3C2B;IP6K2;PIK3R3;...
Small cell lung cancer 1.79 4.50e-2 90/92 (97.83%) CDKN1A;ITGA3;COL4A5;...
Biosynthesis of unsaturated fatty acids 1.76 4.65e-2 21/27 (77.78%) HSD17B4;SCD;ACOX1;...
Arginine and proline metabolism -1.64 4.90e-2 39/50 (78%) AMD1;GAMT;ODC1;...
Glycolysis / Gluconeogenesis -1.65 4.86e-2 56/67 (83.58%) ALDH3B1;TPI1;ALDOA;...
Rheumatoid arthritis -1.66 4.33e-2 78/93 (83.87%) MMP1;IL15;ATP6V1B2;...
Base excision repair -1.68 3.71e-2 29/33 (87.88%) POLD1;POLE3;FEN1;...
Cell cycle -1.68 3.86e-2 110/124 (88.71%) CDK4;E2F1;ORC3;...
Neutrophil extracellular trap formation -1.69 3.70e-2 101/189 (53.44%) MAP2K1;NCF2;HAT1;...
Cysteine and methionine metabolism -1.72 2.93e-2 43/50 (86%) SMS;MPST;MAT1A;...
One carbon pool by folate -1.73 2.94e-2 15/20 (75%) ALDH1L1;GART;SHMT1;...
Drug metabolism -1.74 2.84e-2 78/151 (51.66%) CYP3A4;FMO4;GMPS;...
Ribosome -1.76 2.16e-2 113/158 (71.52%) MRPL17;RPL21;RPL36A;...
Mismatch repair -1.77 2.37e-2 22/23 (95.65%) MLH1;POLD1;EXO1;...
Glycosaminoglycan biosynthesis -1.79 1.32e-2 40/58 (68.97%) B4GALT2;NDST3;B3GNT2;...
Glycine, serine and threonine metabolism -1.87 2.37e-3 31/40 (77.5%) GCAT;PIPOX;GAMT;...
Retinol metabolism -1.89 3.15e-3 41/68 (60.29%) CYP2B6;CYP3A5;CYP2C9;...
Complement and coagulation cascades -1.93 0.00e+0 76/85 (89.41%) CFHR5;SERPINA1;C8G;...
DNA replication -2.30 0.00e+0 34/36 (94.44%) POLD1;POLE3;FEN1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.08uM - 10uM 6H, 24H, 48H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H