Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMGZQEF)

Drug Name
Mifepristone Drug Info
Synonyms
Mifedren; HRA-052015; Mifepristone (Cushing's disease); ACTH modulator (Cushing's disease), HRA; Adrenocorticotropic hormone modulator (Cushing's disease), HRA Pharma; Mifepristone (Cushing's disease), HRA pharma
Cross-matching ID
PubChem CID
55245
ChEBI ID
CHEMBL1276308
CAS Number
CAS 84371-65-3
TTD Drug ID
D0Z4EI
VARIDT Drug ID
DR00714
INTEDE Drug ID
DR1091
ACDINA Drug ID
D00432

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Malaria 2.21 0.00e+0 44/50 (88%) IL1B;CXCL8;COMP;...
Rheumatoid arthritis 2.04 0.00e+0 78/93 (83.87%) IL1B;CXCL1;CXCL6;...
Antigen processing and presentation 2.03 0.00e+0 60/78 (76.92%) CANX;HSPA1A;HLA-DQB1;...
Graft-versus-host disease 2.00 0.00e+0 32/42 (76.19%) IL1B;IL1A;HLA-DQB1;...
Pertussis 1.91 6.62e-3 64/76 (84.21%) IL1B;CALML3;CXCL6;...
Hematopoietic cell lineage 1.88 9.19e-3 90/99 (90.91%) IL1B;IL1A;ITGA6;...
Mucin type O-glycan biosynthesis 1.86 1.10e-2 20/36 (55.56%) GALNT6;ST3GAL1;GALNT7;...
Lipid and atherosclerosis 1.85 1.10e-2 190/215 (88.37%) IL1B;MMP9;CXCL1;...
Tuberculosis 1.83 1.35e-2 159/180 (88.33%) IL1B;CALML3;IL1A;...
Type I diabetes mellitus 1.81 1.65e-2 38/43 (88.37%) IL1B;IL1A;HLA-DQB1;...
Dilated cardiomyopathy 1.80 1.50e-2 86/96 (89.58%) TPM4;ATP2A3;ITGA6;...
Cytokine-cytokine receptor interaction 1.76 2.48e-2 246/295 (83.39%) IL1B;GDF15;CXCL1;...
Inflammatory bowel disease 1.75 2.37e-2 58/65 (89.23%) IL1B;IL1A;HLA-DQB1;...
Protein processing in endoplasmic reticulum 1.74 2.68e-2 127/171 (74.27%) CANX;HSPA1A;HSPA5;...
Fluid shear stress and atherosclerosis 1.72 3.01e-2 123/139 (88.49%) IL1B;MMP9;CALML3;...
N-Glycan biosynthesis 1.69 4.55e-2 38/50 (76%) MGAT2;FUT8;MAN2A1;...
Arrhythmogenic right ventricular cardiomyopathy 1.68 4.28e-2 70/77 (90.91%) ATP2A3;ITGA6;ATP2A2;...
Legionellosis 1.68 4.10e-2 51/57 (89.47%) IL1B;CXCL1;CXCL8;...
Toxoplasmosis 1.67 4.06e-2 103/112 (91.96%) LY96;ALOX5;ITGA6;...
Leishmaniasis 1.65 4.85e-2 67/77 (87.01%) IL1B;CYBA;IL1A;...
Mineral absorption -1.92 2.61e-2 48/60 (80%) VDR;FXYD2;ATP1B2;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Colon
Colon carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 TP53(-/-) CVCL_HD97 Homo sapiens 0.04uM - 10uM 24H
HCT 116 CVCL_0291 Homo sapiens 0.04uM - 10uM 24H
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 (Parent) CVCL_0291 Homo sapiens 0.04uM - 10uM 24H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 8uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 6H, 24H