Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMH01JV)

• Drug Name: cloprostenol Drug Info
• Synonyms: ICI 80996
• Cross-matching ID:
  PubChem CID: 5311053
  CAS Number: CAS 54276-21-0
  TTD Drug ID: D0O9ES

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Ribosome biogenesis in eukaryotes	2.19	0.00e+0	52/108 (48.15%)	FBL;EIF6;NAT10;...
Galactose metabolism	1.86	2.75e-2	26/31 (83.87%)	GLA;PFKP;HK1;...
Phototransduction	1.78	4.97e-2	21/29 (72.41%)	CALML5;CALML3;CALML4
Ferroptosis	-1.89	1.13e-2	36/41 (87.8%)	SAT1;ACSL3;FTH1;...
Autophagy	-1.92	1.13e-2	113/169 (66.86%)	PIK3CB;RAB7A;PRKAA1;...
Complement and coagulation cascades	-2.16	0.00e+0	76/85 (89.41%)	CPB2;C9;TFPI;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲