Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMH24GL)

Drug Name
[3H]GABA Drug Info
Synonyms 4-ammoniobutanoate; 4-azaniumylbutanoate; 4euo; gamma-amino-N-butyrate; g-amino-n-butyric acid; 3ip9; CHEBI:59888; gamma-aminobutyric acid zwitterion; CJ-05261
Cross-matching ID
PubChem CID
119
ChEBI ID
CHEMBL96
CAS Number
CAS 56-12-2
TTD Drug ID
D04QAC

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.40 0.00e+0 34/36 (94.44%) PCNA;RPA3;SSBP1;...
Mismatch repair 2.30 0.00e+0 22/23 (95.65%) PCNA;RPA3;SSBP1;...
Spliceosome 2.11 0.00e+0 101/150 (67.33%) LSM5;HSPA2;SNRPD1;...
Glycine, serine and threonine metabolism 2.10 0.00e+0 31/40 (77.5%) PSAT1;PGAM1;BHMT;...
Mineral absorption 2.04 0.00e+0 48/60 (80%) MT1X;MT1E;MT1F;...
Type I diabetes mellitus 1.98 0.00e+0 38/43 (88.37%) HLA-B;HLA-DRA;GZMB;...
Retinol metabolism 1.98 0.00e+0 41/68 (60.29%) ALDH1A2;ALDH1A3;CYP1A1;...
Graft-versus-host disease 1.96 1.13e-3 32/42 (76.19%) HLA-B;HLA-DRA;GZMB;...
Allograft rejection 1.88 1.00e-3 32/38 (84.21%) HLA-B;HLA-DRA;GZMB;...
Antigen processing and presentation 1.84 2.71e-3 60/78 (76.92%) HSPA2;CD74;HLA-B;...
Complement and coagulation cascades 1.83 3.29e-3 76/85 (89.41%) CFI;CLU;CFB;...
Autoimmune thyroid disease 1.80 3.01e-3 46/53 (86.79%) HLA-B;HLA-DRA;GZMB;...
Nucleotide excision repair 1.80 4.87e-3 40/47 (85.11%) PCNA;RAD23B;RPA3;...
Tryptophan metabolism 1.79 5.17e-3 35/42 (83.33%) IDO1;AOC1;CYP1A1;...
Systemic lupus erythematosus 1.76 8.44e-3 45/135 (33.33%) HLA-DRA;SNRPD1;C3;...
Ubiquinone and other terpenoid-quinone biosynthesis 1.75 8.48e-3 9/11 (81.82%) HPD;COQ3;TAT;...
Arginine and proline metabolism 1.74 1.01e-2 39/50 (78%) SAT1;AOC1;MAOB;...
Cysteine and methionine metabolism 1.73 1.00e-2 43/50 (86%) PSAT1;BHMT;BCAT1;...
Proteasome 1.70 1.48e-2 44/46 (95.65%) PSMB10;PSMB8;PSMA2;...
Tyrosine metabolism 1.67 2.44e-2 30/36 (83.33%) TYRP1;MAOB;TYR;...
Aminoacyl-tRNA biosynthesis 1.64 2.97e-2 15/66 (22.73%) LARS2;GATC;IARS2;...
Histidine metabolism 1.64 2.96e-2 16/22 (72.73%) AOC1;MAOB;HNMT;...
Cell cycle 1.61 4.09e-2 110/124 (88.71%) PCNA;CHEK1;SMC1A;...
Drug metabolism 1.61 3.96e-2 78/151 (51.66%) RRM1;MAOB;FMO1;...
Terpenoid backbone biosynthesis -1.74 4.41e-2 18/22 (81.82%) HMGCR;MVD;HMGCS2;...
Collecting duct acid secretion -1.85 1.76e-2 22/27 (81.48%) ATP6V1D;ATP6V1E1;ATP6V0A1;...
Phosphatidylinositol signaling system -1.94 8.27e-3 82/97 (84.54%) PLCB2;PRKCB;INPPL1;...
Amino sugar and nucleotide sugar metabolism -2.04 0.00e+0 38/48 (79.17%) GNE;GMDS;PGM3;...
Lysosome -2.04 0.00e+0 115/128 (89.84%) SORT1;GLB1;AP1M2;...
Steroid biosynthesis -2.12 0.00e+0 19/20 (95%) LIPA;DHCR24;FDFT1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.37uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.37uM - 10uM 24H
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H2110 CVCL_1529 Homo sapiens 3.33uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H