Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMH4ANG)

Drug Name
HMN-214 Drug Info
Synonyms N-(4-methoxyphenyl)sulfonyl-N-[2-[(E)-2-(1-oxidopyridin-4-yl)ethenyl]phenyl]acetamide; (E)-4-(2-(2-(N-Acetyl-N-((p-methoxyphenyl)sulfonyl)amino)phenyl)ethenyl)pyridine 1-oxide
Therapeutic ClassAnticancer Agents
Cross-matching ID
PubChem CID
9888590
ChEBI ID
CHEMBL3991927
CAS Number
CAS 173529-46-9
TTD Drug ID
D0R7ID

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Mineral absorption 2.05 0.00e+0 48/60 (80%) MT1E;MT1H;MT1G;...
Progesterone-mediated oocyte maturation 2.05 0.00e+0 75/100 (75%) PLK1;AURKA;CCNB2;...
Amoebiasis 1.90 1.14e-2 99/102 (97.06%) CXCL3;CXCL1;CXCL8;...
Focal adhesion 1.84 1.70e-2 180/201 (89.55%) ITGA6;CAV1;CAV2;...
Amino sugar and nucleotide sugar metabolism -1.69 3.04e-2 38/48 (79.17%) UGP2;HK2;NAGK;...
Staphylococcus aureus infection -1.72 2.47e-2 72/95 (75.79%) HLA-DQA1;HLA-DRA;C5;...
Glycolysis / Gluconeogenesis -1.73 2.17e-2 56/67 (83.58%) ADH1B;BPGM;PCK2;...
Steroid hormone biosynthesis -1.82 1.03e-2 43/61 (70.49%) UGT2B4;CYP21A2;CYP17A1;...
Glutathione metabolism -1.83 1.04e-2 43/57 (75.44%) G6PD;GSTM1;GSTM2;...
Pentose and glucuronate interconversions -1.86 9.65e-3 17/34 (50%) UGT2B4;UGP2;AKR1B1;...
Folate biosynthesis -1.87 8.68e-3 23/26 (88.46%) AKR1B1;MOCOS;GCH1;...
Ascorbate and aldarate metabolism -1.87 9.92e-3 15/30 (50%) UGT2B15;AKR1A1;UGT2A3;...
Fanconi anemia pathway -1.90 1.01e-2 36/54 (66.67%) ERCC1;MLH1;FANCE;...
Drug metabolism -1.92 1.04e-2 78/151 (51.66%) ADH5;CYP2C9;NME6;...
Mismatch repair -1.94 1.09e-2 22/23 (95.65%) MLH1;RPA2;EXO1;...
Sulfur metabolism -2.02 5.79e-3 9/10 (90%) SUOX;TST;PAPSS2;...
Metabolism of xenobiotics by cytochrome P450 -2.20 0.00e+0 49/77 (63.64%) ADH5;CYP2C9;GSTM1;...
DNA replication -2.36 0.00e+0 34/36 (94.44%) MCM7;POLA1;DNA2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 6H, 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.08uM - 10uM 6H, 24H, XH
Breast carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-20 CVCL_0178 Homo sapiens 0.08uM - 10uM 6H, 24H
Hs 578T CVCL_0332 Homo sapiens 0.08uM - 10uM 6H, 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.03uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H, XH
NCI-H508 CVCL_1561 Homo sapiens 0.66uM - 10uM XH
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H, XH
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H, XH
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
NCI-H1975 CVCL_1511 Homo sapiens 0.66uM - 10uM XH
NCI-H1975 CVCL_1511 Homo sapiens 0.66uM - 10uM XH
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 0.66uM - 10uM XH
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 0.66uM - 10uM XH
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SU-DHL-4 CVCL_0539 Homo sapiens 0.66uM - 10uM XH
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H, XH
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H, XH
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H