General Information of Drug (ID: DMH4C3M)

Drug Name
STA-5326 Drug Info
Synonyms Apilimod; STA 5326; STA5326; N-[(3-methylphenyl)methylideneamino]-6-morpholin-4-yl-2-(2-pyridin-2-ylethoxy)pyrimidin-4-amine
Cross-matching ID
PubChem CID
10173277
ChEBI ID
CHEMBL4297643
CAS Number
CAS 541550-19-0
TTD Drug ID
D0C9NJ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Lysosome 2.77 0.00e+0 115/128 (89.84%) NEU1;NPC2;CTSA;...
Steroid biosynthesis 2.63 0.00e+0 19/20 (95%) MSMO1;LSS;DHCR24;...
Valine, leucine and isoleucine degradation 2.27 0.00e+0 42/48 (87.5%) HMGCS1;ACAT2;AACS;...
Vibrio cholerae infection 2.22 0.00e+0 44/50 (88%) ATP6V0E1;ATP6V1E1;ATP6V1G1;...
Terpenoid backbone biosynthesis 2.22 0.00e+0 18/22 (81.82%) HMGCS1;ACAT2;FDPS;...
Synaptic vesicle cycle 2.14 0.00e+0 63/78 (80.77%) ATP6V0E1;ATP6V1E1;STX3;...
Sphingolipid metabolism 2.11 0.00e+0 32/49 (65.31%) NEU1;ASAH1;PSAP;...
Galactose metabolism 2.11 0.00e+0 26/31 (83.87%) GALE;AKR1B10;PFKP;...
Fatty acid biosynthesis 2.07 0.00e+0 16/18 (88.89%) ACSL1;ACSL3;FASN;...
Glyoxylate and dicarboxylate metabolism 2.02 5.83e-3 23/30 (76.67%) ACAT2;ACO1;ACO2;...
Amino sugar and nucleotide sugar metabolism 2.01 6.36e-3 38/48 (79.17%) GNPDA1;GALE;AMDHD2;...
Glycolysis / Gluconeogenesis 1.98 6.80e-3 56/67 (83.58%) ALDOC;ENO2;ALDH2;...
Autophagy 1.98 6.27e-3 113/169 (66.86%) SQSTM1;RRAGD;IRS2;...
Biosynthesis of unsaturated fatty acids 1.98 5.83e-3 21/27 (77.78%) SCD;FADS1;FADS2;...
Other glycan degradation 1.97 5.44e-3 13/18 (72.22%) NEU1;FUCA1;HEXB;...
PPAR signaling pathway 1.97 5.10e-3 66/74 (89.19%) HMGCS1;SCD;ACSL1;...
Collecting duct acid secretion 1.97 4.80e-3 22/27 (81.48%) ATP6V0E1;ATP6V1E1;ATP6V1G1;...
Peroxisome 1.95 4.53e-3 72/82 (87.8%) IDH1;ACSL1;ACSL3;...
Glycosaminoglycan degradation 1.94 4.29e-3 19/19 (100%) HEXB;GNS;HEXA;...
Pentose phosphate pathway 1.93 4.08e-3 25/30 (83.33%) ALDOC;PGD;G6PD;...
Rheumatoid arthritis 1.93 3.88e-3 78/93 (83.87%) TLR4;ATP6V0E1;CTSL;...
Fructose and mannose metabolism 1.90 4.24e-3 30/33 (90.91%) ALDOC;SORD;AKR1B10;...
Synthesis and degradation of ketone bodies 1.89 4.05e-3 9/10 (90%) HMGCS1;ACAT2;HMGCL
Epithelial cell signaling in Helicobacter pylori infect... 1.88 4.86e-3 62/70 (88.57%) ATP6V0E1;ATP6V1E1;ATP6V1G1;...
Metabolism of xenobiotics by cytochrome P450 1.88 5.13e-3 49/77 (63.64%) AKR1C1;EPHX1;CYP1B1;...
Butanoate metabolism 1.86 5.83e-3 23/28 (82.14%) HMGCS1;ACAT2;AACS;...
Mucin type O-glycan biosynthesis 1.85 6.47e-3 20/36 (55.56%) GALNT12;GALNT7;GCNT3;...
mTOR signaling pathway 1.85 6.24e-3 114/154 (74.03%) RRAGD;DDIT4;LPIN1;...
Phagosome 1.81 7.28e-3 118/152 (77.63%) LAMP1;TLR4;ATP6V0E1;...
Inositol phosphate metabolism 1.81 7.42e-3 66/73 (90.41%) CDIPT;IMPA2;PIK3CD;...
Nucleotide excision repair -1.62 3.31e-2 40/47 (85.11%) DDB2;LIG1;GTF2H4;...
Graft-versus-host disease -1.63 3.10e-2 32/42 (76.19%) KLRD1;HLA-DOB;TNF;...
Proteasome -1.64 2.58e-2 44/46 (95.65%) PSMB10;PSMD3;PSMC1;...
Asthma -1.65 2.73e-2 25/31 (80.65%) PRG2;IL9;FCER1G;...
mRNA surveillance pathway -1.65 2.90e-2 71/98 (72.45%) GSPT1;SYMPK;PPP2R5D;...
Homologous recombination -1.66 2.80e-2 35/41 (85.37%) MRE11;NBN;RAD51C;...
RNA degradation -1.70 2.15e-2 53/79 (67.09%) LSM4;CNOT9;PAN2;...
Allograft rejection -1.70 2.32e-2 32/38 (84.21%) HLA-DOB;TNF;HLA-DQA1;...
Systemic lupus erythematosus -1.72 1.84e-2 45/135 (33.33%) SSB;C1QA;ELANE;...
Pyrimidine metabolism -1.82 7.36e-3 40/56 (71.43%) DTYMK;UMPS;DCTPP1;...
Fanconi anemia pathway -1.84 7.36e-3 36/54 (66.67%) REV1;RMI1;FAAP100;...
Base excision repair -1.86 5.72e-3 29/33 (87.88%) POLB;PARP1;LIG1;...
Mismatch repair -1.93 9.20e-4 22/23 (95.65%) LIG1;SSBP1;RPA2;...
RNA polymerase -1.96 1.05e-3 23/31 (74.19%) POLR1B;POLR2G;POLR2A;...
Cell cycle -2.01 0.00e+0 110/124 (88.71%) CDK7;CUL1;ANAPC5;...
Ribosome biogenesis in eukaryotes -2.16 0.00e+0 52/108 (48.15%) RIOK2;CSNK2A1;BMS1;...
Ribosome -2.32 0.00e+0 113/158 (71.52%) MRPL24;RPL9;RPL31;...
RNA transport -2.32 0.00e+0 128/186 (68.82%) NUP98;NUP62;RPP14;...
DNA replication -2.40 0.00e+0 34/36 (94.44%) RFC1;MCM3;RNASEH2A;...
Spliceosome -2.59 0.00e+0 101/150 (67.33%) HSPA6;SART1;SF3B3;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H