Details of the Drug Pharmacogenomic Perturbation Atlas

Dipivefrin Drug Info

AKPro; Dipivefrina; Dipivefrine; Dipivefrinum; Propine; Dipivalyl epinephrine; Dipivefrin HCL; Dipivefrin [USAN]; K 30081; Dipivefrin (USAN); Dipivefrina [INN-Spanish]; Dipivefrine (INN); Dipivefrinum [INN-Latin]; Ophtho-Dipivefrin; Propine C Cap B.I.D.; [2-(2,2-dimethylpropanoyloxy)-4-[1-hydroxy-2-(methylamino)ethyl]phenyl] 2,2-dimethylpropanoate; (+-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol 3,4-dipivalate; (+-)-4-[1-hydroxy-2-(methylamino)ethyl]-o-phenylene divavalate; (-)-2,2-Dimethylpropansaeure-4-(1-hydroxy-2-(methylamino)ethyl)-1,2-phenylenester; (-)-4-(1-Hydroxy-2-methylaminoethyl)-o-phenylendipivalat; (RS)-4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-phenylen dipivalat; 1-(3',4'-dipivaloyloxyphenyl)-2-methylamino-1-ethanol; 2,2-Dimethylpropanoic acid 4-[1-hydroxy-2-(methylamino)ethyl]-1,2-phenylene ester; 4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-phenylen dipivalat; 4-[1-hydroxy-2-(methylamino)ethyl]-o-phenylene divavalate; 4-[1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diyl bis(2,2-dimethylpropanoate)

Therapeutic Class

Ophthalmologicals

Cross-matching ID

PubChem CID

3105

ChEBI ID

CHEMBL4646

CAS Number

CAS 52365-63-6

TTD Drug ID

D01JFT

ACDINA Drug ID

D01008

General Information of Drug (ID: DMH5W0G)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Synaptic vesicle cycle	-1.66	4.57e-2	63/78 (80.77%)	ATP6V1B2;SNAP25;SLC6A7;...
Folate biosynthesis	-1.68	4.06e-2	23/26 (88.46%)	PCBD1;ALPI;ALPG;...
Cytokine-cytokine receptor interaction	-1.69	4.00e-2	246/295 (83.39%)	CSF3;CCR3;IL17RB;...
Viral protein interaction with cytokine and cytokine re...	-1.70	4.14e-2	84/100 (84%)	IL22RA1;IL18;CXCR2;...
Glycolysis / Gluconeogenesis	-1.71	3.71e-2	56/67 (83.58%)	HKDC1;ADH1C;FBP2;...
Viral myocarditis	-1.72	3.36e-2	53/60 (88.33%)	SGCD;EIF4G3;CD40;...
Graft-versus-host disease	-1.82	1.52e-2	32/42 (76.19%)	IL2;IL1A;HLA-F;...
IL-17 signaling pathway	-1.85	7.87e-3	84/94 (89.36%)	TRAF3IP2;MMP13;JUN;...
Inflammatory bowel disease	-1.85	8.74e-3	58/65 (89.23%)	MAF;IL21R;FOXP3;...
Phagosome	-1.87	8.61e-3	118/152 (77.63%)	FCGR2C;ITGB3;DYNC1I1;...
Mucin type O-glycan biosynthesis	-1.88	9.84e-3	20/36 (55.56%)	GALNT1;ST6GALNAC4;GALNT11;...
Oxidative phosphorylation	-1.97	0.00e+0	93/133 (69.92%)	NDUFA8;NDUFS7;ATP5MF;...
Epithelial cell signaling in Helicobacter pylori infect...	-1.98	0.00e+0	62/70 (88.57%)	ATP6V1F;ATP6V0C;ATP6V0D1;...
Collecting duct acid secretion	-2.01	0.00e+0	22/27 (81.48%)	ATP6V1B2;ATP4B;CLCNKB;...
Legionellosis	-2.03	0.00e+0	51/57 (89.47%)	CR1;VCP;ARF1;...
Vibrio cholerae infection	-2.17	0.00e+0	44/50 (88%)	ATP6V0A4;KCNQ1;TJP1;...
Rheumatoid arthritis	-2.39	0.00e+0	78/93 (83.87%)	IL15;TNFSF13;ATP6V0A4;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	4uM	6H

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H, 24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H, 24H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H

Prostate

Prostate carcinoma

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H, 24H