Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMHA5ME)

Drug Name
AZD-9684 Drug Info
Synonyms
Laudanosine; DL-Laudanosine; 1699-51-0; (+-)-Laudanosine; Laudanosine (R,S); (R,S)-Laudanosine; EINECS 216-923-9; NSC 94267; AI3-61890; 20412-65-1; NSC35045; 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline; (+-)-1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methyl-1-veratrylisoquinoline; 1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline; ISOQUINOLINE, 1,2,3,4-TETRAHYDRO-6,7-DIMETHOXY-2-METHYL-1-VERATRYL-, (+-)-
Cross-matching ID
PubChem CID
87609775
ChEBI ID
CHEMBL3235130
TTD Drug ID
D0F7FX

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Hypertrophic cardiomyopathy -1.71 4.48e-2 81/90 (90%) PRKAG2;ITGA8;SGCG;...
Adrenergic signaling in cardiomyocytes -1.74 3.37e-2 130/150 (86.67%) AGT;PPP1CA;CACNA2D3;...
Arginine biosynthesis -1.75 3.59e-2 17/22 (77.27%) NOS2;ARG2;GLS;...
Porphyrin and chlorophyll metabolism -1.78 2.46e-2 23/43 (53.49%) ALAS2;UGT2B17;ALAS1;...
Dilated cardiomyopathy -1.79 2.56e-2 86/96 (89.58%) PRKACB;ITGA8;SGCG;...
Amphetamine addiction -1.88 1.37e-2 57/69 (82.61%) GRIA3;PRKACB;PPP3CA;...
Insulin secretion -1.91 1.54e-2 75/86 (87.21%) SNAP25;KCNN3;PRKACB;...
Cardiac muscle contraction -2.02 0.00e+0 64/87 (73.56%) COX5A;COX7A2L;CACNA1C;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H