Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMHATCZ)

• Drug Name: Tpl2 kinase inhibitor Drug Info
• Synonyms: Tpl2 Kinase Inhibitor; 871307-18-5; 4-((3-Chloro-4-fluorophenyl)amino)-6-((pyridin-3-ylmethyl)amino)-1,7-naphthyridine-3-carbonitrile; CHEMBL200381; 4-[(3-CHLORO-4-FLUOROPHENYL)AMINO]-6-[(3-PYRIDINYLMETHYL)AMINO]-1,7-NAPHTHYRIDINE-3-CARBONITRILE; 4-(3-Chloro-4-fluorophenylamino)-6-(pyridin-3-yl-methylamino)-3-cyano-[1,7]-naphthyridine; K00599a; 4-[(3-chloro-4-fluorophenyl)amino]-6-[(pyridin-3-ylmethyl)amino]-1,7-naphthyridine-3-carbonitrile
• Cross-matching ID:
  PubChem CID: 9549300
  ChEBI ID: CHEMBL200381
  CAS Number: CAS 871307-18-5
  TTD Drug ID: D06KSF

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Asthma	2.01	7.98e-3	25/31 (80.65%)	HLA-DRA;HLA-DPA1;HLA-DRB1;...
Protein digestion and absorption	1.99	3.99e-3	78/103 (75.73%)	COL3A1;COL1A2;COL5A2;...
Viral myocarditis	1.93	2.66e-3	53/60 (88.33%)	HLA-DRA;HLA-DPA1;HLA-DRB1;...
Allograft rejection	1.90	5.98e-3	32/38 (84.21%)	HLA-DRA;HLA-DPA1;HLA-DRB1;...
DNA replication	1.85	1.76e-2	34/36 (94.44%)	PCNA;MCM5;POLD3;...
Graft-versus-host disease	1.85	1.46e-2	32/42 (76.19%)	HLA-DRA;HLA-DPA1;HLA-DRB1;...
Autoimmune thyroid disease	1.83	1.48e-2	46/53 (86.79%)	HLA-DRA;HLA-DPA1;HLA-DRB1;...
Type I diabetes mellitus	1.82	1.30e-2	38/43 (88.37%)	HLA-DRA;HLA-DPA1;HLA-DRB1;...
Glycine, serine and threonine metabolism	1.78	2.04e-2	31/40 (77.5%)	PSAT1;GATM;SHMT2;...
Intestinal immune network for IgA production	1.70	3.35e-2	38/48 (79.17%)	HLA-DRA;HLA-DPA1;HLA-DRB1;...
Selenocompound metabolism	1.70	3.26e-2	11/17 (64.71%)	SEPHS1;CTH;PAPSS1;...
Antigen processing and presentation	1.69	3.12e-2	60/78 (76.92%)	HLA-DRA;HLA-DPA1;HLA-DRB1;...
Base excision repair	1.63	4.84e-2	29/33 (87.88%)	PCNA;HMGB1;POLD3;...
Biosynthesis of unsaturated fatty acids	-1.70	4.52e-2	21/27 (77.78%)	BAAT;HSD17B12;SCP2;...
Tryptophan metabolism	-1.72	3.95e-2	35/42 (83.33%)	MAOA;DHTKD1;CYP1A2;...
Ferroptosis	-1.75	2.89e-2	36/41 (87.8%)	STEAP3;ACSL3;VDAC2;...
Colorectal cancer	-1.76	2.55e-2	84/86 (97.67%)	BCL2;AKT2;PIK3R1;...
Retinol metabolism	-1.79	2.11e-2	41/68 (60.29%)	ADH5;ADH1B;UGT2B4;...
B cell receptor signaling pathway	-1.80	1.72e-2	71/81 (87.65%)	IKBKB;DAPP1;CD81;...
Cholesterol metabolism	-1.91	2.01e-3	44/50 (88%)	LIPC;CETP;APOA4;...
Terpenoid backbone biosynthesis	-1.93	2.41e-3	18/22 (81.82%)	HMGCR;MVK;FNTA;...
Complement and coagulation cascades	-1.97	3.01e-3	76/85 (89.41%)	SERPINA5;PLAU;FGB;...
Mineral absorption	-2.00	4.02e-3	48/60 (80%)	CYBRD1;MT2A;MT1F;...
IL-17 signaling pathway	-2.07	6.03e-3	84/94 (89.36%)	IL17RA;LCN2;GSK3B;...
Steroid biosynthesis	-2.17	0.00e+0	19/20 (95%)	FDFT1;CYP51A1;SQLE;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 10uM	24H	Hide ▲

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 10uM	24H	Hide ▲