Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMHD3R8)

Drug Name
D-4476 Drug Info
Synonyms CK1 inhibitor; D 4476
Cross-matching ID
PubChem CID
6419753
ChEBI ID
CHEMBL410456
CAS Number
CAS 301836-43-1
TTD Drug ID
D00JGL

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.27 0.00e+0 19/20 (95%) MSMO1;LSS;DHCR7;...
Amino sugar and nucleotide sugar metabolism 2.18 0.00e+0 38/48 (79.17%) GNPDA1;AMDHD2;HK2;...
Terpenoid backbone biosynthesis 1.99 3.50e-3 18/22 (81.82%) IDI1;HMGCS1;HMGCR;...
Galactose metabolism 1.96 7.88e-3 26/31 (83.87%) HK2;GALE;PFKP;...
DNA replication 1.93 8.41e-3 34/36 (94.44%) RPA3;POLD2;FEN1;...
Pentose phosphate pathway 1.85 1.23e-2 25/30 (83.33%) G6PD;PGD;TKT;...
Biosynthesis of unsaturated fatty acids 1.79 3.00e-2 21/27 (77.78%) SCD;ELOVL6;FADS1;...
Glyoxylate and dicarboxylate metabolism 1.78 3.02e-2 23/30 (76.67%) SHMT2;GLDC;ACAT2;...
Central carbon metabolism in cancer 1.78 2.92e-2 67/70 (95.71%) HK2;G6PD;IDH1;...
Starch and sucrose metabolism 1.75 3.15e-2 25/36 (69.44%) HK2;MGAM;HK1;...
Glutathione metabolism 1.70 4.49e-2 43/57 (75.44%) G6PD;IDH1;PGD;...
Fructose and mannose metabolism 1.69 4.64e-2 30/33 (90.91%) HK2;PMM1;PFKP;...
Complement and coagulation cascades -1.70 3.77e-2 76/85 (89.41%) A2M;KNG1;CFI;...
Protein export -1.71 3.85e-2 17/23 (73.91%) SEC61A1;SRPRA;SEC61B;...
Proteoglycans in cancer -1.74 2.54e-2 172/205 (83.9%) RRAS;ITGA5;FZD8;...
Tight junction -1.74 2.72e-2 130/169 (76.92%) CFTR;RAP1A;MYL6;...
Hippo signaling pathway -1.86 7.06e-3 120/186 (64.52%) ID2;FBXW11;TP53BP2;...
Malaria -1.87 6.72e-3 44/50 (88%) SELP;CCL2;ITGAL;...
Dilated cardiomyopathy -1.88 6.28e-3 86/96 (89.58%) ITGA2;PLN;ITGA5;...
Focal adhesion -1.92 7.53e-3 180/201 (89.55%) RAP1A;CCND2;SOS2;...
Arrhythmogenic right ventricular cardiomyopathy -1.95 9.41e-3 70/77 (90.91%) ITGA2;ITGA5;LAMA2;...
ECM-receptor interaction -1.96 6.28e-3 80/88 (90.91%) ITGA5;COL4A5;LAMA2;...
Hypertrophic cardiomyopathy -2.00 9.41e-3 81/90 (90%) ITGA5;LAMA2;CACNA1D;...
TGF-beta signaling pathway -2.00 1.88e-2 81/94 (86.17%) BMP4;PPP2CA;PPP2R1A;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 20uM 6H, 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 20uM 6H, 24H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 20uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 20uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 20uM 6H, 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 20uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 20uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 20uM 6H, 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H