Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMHD4PE)

Drug Name
Desvenlafaxine Drug Info
Synonyms Norvenlafaxine; Desvenlafaxine (INN); Desvenlafaxine [INN:BAN]; O-Desmethylvenlafaxine; WY 45,233; O-DESMETHYLVENLAFAXINE (ODV); WY-45,233
Cross-matching ID
PubChem CID
125017
ChEBI ID
CHEMBL83527
CAS Number
CAS 93413-62-8
TTD Drug ID
D0O3FG
VARIDT Drug ID
DR01008
ACDINA Drug ID
D00182

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Mucin type O-glycan biosynthesis 1.82 4.77e-2 20/36 (55.56%) ST6GALNAC2;C1GALT1;ST3GAL1;...
Ribosome biogenesis in eukaryotes 1.81 3.18e-2 52/108 (48.15%) NVL;NMD3;DROSHA;...
DNA replication 1.78 4.24e-2 34/36 (94.44%) PCNA;RPA3;POLD2;...
Steroid biosynthesis -1.71 4.41e-2 19/20 (95%) LIPA;FDFT1;SQLE;...
Fatty acid elongation -1.73 3.66e-2 19/27 (70.37%) PPT1;HADHB;ACOT7;...
Terpenoid backbone biosynthesis -1.74 3.51e-2 18/22 (81.82%) HMGCR;HMGCS2;FNTA;...
Mineral absorption -1.81 1.57e-2 48/60 (80%) ATP1A3;FTL;ATP2B2;...
Fat digestion and absorption -1.81 1.89e-2 35/43 (81.4%) PLA2G2A;ABCA1;AGPAT2;...
Butanoate metabolism -1.87 1.89e-2 23/28 (82.14%) GAD2;HMGCL;ACSM3;...
PPAR signaling pathway -1.90 1.89e-2 66/74 (89.19%) ILK;SORBS1;FABP7;...
Biosynthesis of unsaturated fatty acids -2.03 4.72e-3 21/27 (77.78%) FADS2;ACOT7;ELOVL1;...
Cholesterol metabolism -2.16 9.44e-3 44/50 (88%) VDAC2;CYP27A1;SORT1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 2.22uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H