Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMHG57U)

Drug Name
OPC-34712 Drug Info
Synonyms Brexpiprazole
Cross-matching ID
PubChem CID
11978813
ChEBI ID
CHEMBL2105760
CAS Number
CAS 913611-97-9
TTD Drug ID
D0P0OU
VARIDT Drug ID
DR01335
INTEDE Drug ID
DR0227
ACDINA Drug ID
D00076

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Relaxin signaling pathway 1.74 4.93e-2 114/129 (88.37%) GNAI1;TGFB1;ADCY1;...
Oxidative phosphorylation -1.75 2.60e-2 93/133 (69.92%) NDUFS3;ATP5MC3;NDUFB8;...
Prion disease -1.79 2.07e-2 209/273 (76.56%) NDUFB1;MAPK10;ATP5F1A;...
Retinol metabolism -1.81 1.75e-2 41/68 (60.29%) ADH1A;RPE65;RDH5;...
Amyotrophic lateral sclerosis -1.82 1.46e-2 267/364 (73.35%) PSMD2;DCTN3;NDUFB1;...
Huntington disease -1.87 1.22e-2 233/306 (76.14%) PSMD2;DCTN3;NDUFB1;...
Proteasome -2.03 3.65e-3 44/46 (95.65%) PSMD2;PSME4;PSMA2;...
Parkinson disease -2.21 0.00e+0 176/249 (70.68%) CAMK2G;MAPT;NDUFA4L2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 2.22uM 24H