Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMHIDUE)

Drug Name
Phenelzine Drug Info
Synonyms
Fenelzina; Fenelzyna; Fenelzyne; Phenelezine; Phenelzinum; Phenethylhydrazine; Phenylethylhydrazine; Fenelzyna [Polish]; Fenelzyne [Polish]; W1544; Beta-Phenylethylhydrazine; Fenelzina [INN-Spanish]; Nardelzine (TN); Nardil (TN); Phenelzine (BAN); Phenelzine [INN:BAN]; Phenelzinum [INN-Latin]; Phenylethyl hydrazine-HCl; W 1544-A; 1-Hydrazino-2-phenylethane; 2-Phenethylhydrazine; 2-Phenylethylhydrazine
Therapeutic ClassAntidepressants
Cross-matching ID
PubChem CID
3675
ChEBI ID
CHEMBL1089
CAS Number
CAS 51-71-8
TTD Drug ID
D0P9AC
INTEDE Drug ID
DR1272
ACDINA Drug ID
D00524

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Spliceosome 2.40 0.00e+0 101/150 (67.33%) SRSF1;HSPA8;PUF60;...
DNA replication 2.27 0.00e+0 34/36 (94.44%) MCM4;POLE2;PCNA;...
Base excision repair 2.18 0.00e+0 29/33 (87.88%) PARP2;APEX1;POLE2;...
Cell cycle 2.09 0.00e+0 110/124 (88.71%) CCNA2;WEE1;MCM4;...
RNA transport 2.07 0.00e+0 128/186 (68.82%) EIF2S3;NUP37;PNN;...
Ribosome biogenesis in eukaryotes 2.04 0.00e+0 52/108 (48.15%) RAN;RPP38;PWP2;...
Nucleotide excision repair 1.92 3.71e-3 40/47 (85.11%) POLE2;PCNA;GTF2H3;...
Mismatch repair 1.92 4.33e-3 22/23 (95.65%) PCNA;SSBP1;MSH2;...
Homologous recombination 1.85 6.73e-3 35/41 (85.37%) BRCA1;RAD54B;BARD1;...
Cellular senescence 1.82 7.79e-3 139/156 (89.1%) CCNA2;NFATC3;RBBP4;...
TGF-beta signaling pathway 1.74 1.97e-2 81/94 (86.17%) ID1;THBS1;ID3;...
Ribosome 1.73 2.38e-2 113/158 (71.52%) MRPL35;MRPL15;MRPS16;...
Fanconi anemia pathway 1.72 2.60e-2 36/54 (66.67%) BRCA1;RAD51;MLH1;...
Amyotrophic lateral sclerosis 1.67 4.58e-2 267/364 (73.35%) SRSF7;NUP37;PSMC3;...
Porphyrin and chlorophyll metabolism -1.68 4.84e-2 23/43 (53.49%) BLVRA;UGT2B17;FECH;...
Ascorbate and aldarate metabolism -1.71 3.73e-2 15/30 (50%) UGT2A3;UGT2B15;RGN;...
Amino sugar and nucleotide sugar metabolism -1.72 3.48e-2 38/48 (79.17%) HK3;MPI;RENBP;...
Mineral absorption -1.73 3.69e-2 48/60 (80%) ATP1B1;FTL;TRPV6;...
Rheumatoid arthritis -1.75 3.50e-2 78/93 (83.87%) ATP6V0C;ATP6V0B;TLR2;...
Arginine and proline metabolism -1.78 2.26e-2 39/50 (78%) ALDH3A2;PRODH2;PYCR1;...
Hematopoietic cell lineage -1.81 1.83e-2 90/99 (90.91%) CD1A;EPOR;KITLG;...
Pertussis -1.89 4.84e-3 64/76 (84.21%) C1R;ITGB1;ITGA5;...
Riboflavin metabolism -1.89 5.65e-3 7/8 (87.5%) RFK;ENPP1;ACP5;...
Lysosome -1.90 6.77e-3 115/128 (89.84%) AGA;CLN5;GNPTAB;...
Cytokine-cytokine receptor interaction -1.91 8.47e-3 246/295 (83.39%) GDF15;IL36RN;TNFRSF11A;...
Staphylococcus aureus infection -1.98 3.76e-3 72/95 (75.79%) CFH;C1R;ITGB2;...
Viral protein interaction with cytokine and cytokine re... -2.19 0.00e+0 84/100 (84%) LTBR;IL18RAP;CCL18;...
Steroid biosynthesis -2.36 0.00e+0 19/20 (95%) HSD17B7;TM7SF2;SC5D;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H