Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMHKUBG)

• Drug Name: vesamicol Drug Info
• Synonyms: vesamicol; VESAMICOL HYDROCHLORIDE; 22232-64-0; CHEMBL20943; MLS000554350; 2-(4-Phenyl-piperidin-1-yl)-cyclohexanol; Cyclohexanol, 2-(4-phenyl-1-piperidinyl)-; 2-(4-phenylpiperidin-1-yl)cyclohexan-1-ol; AH-5183; 2-(4-Phenyl-1-piperidinyl)cyclohexanol; SMR000146667; 2-(4-Phenylpiperidino)cyclohexanol; 23965-53-9; V-100; Spectrum_000292; Opera_ID_322; AC1Q7BAI; AC1L1KUQ; Prestwick1_000920; Spectrum3_001861; Prestwick0_000920; Prestwick2_000920; Oprea1_778558; Lopac0_001228; Oprea1_695768; KBioSS_000772; BSPBio_003302; MLS001201728
• Cross-matching ID:
  PubChem CID: 5662
  ChEBI ID: CHEMBL20943
  CAS Number: CAS 22232-64-0
  TTD Drug ID: D0I1QF
  VARIDT Drug ID: DR00964

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Cell cycle	2.21	0.00e+0	110/124 (88.71%)	PLK1;CDKN1B;CDKN2C;...
DNA replication	2.17	0.00e+0	34/36 (94.44%)	PCNA;RFC5;MCM7;...
Fanconi anemia pathway	2.02	3.50e-3	36/54 (66.67%)	FANCI;FANCL;RPA3;...
Mismatch repair	1.98	5.26e-3	22/23 (95.65%)	PCNA;RFC5;MSH2;...
Homologous recombination	1.96	4.21e-3	35/41 (85.37%)	BARD1;RPA3;RAD54B;...
Spliceosome	1.79	1.93e-2	101/150 (67.33%)	PRPF4;PUF60;RBMX;...
RNA degradation	1.75	3.45e-2	53/79 (67.09%)	PAN2;EXOSC2;MTREX;...
Ribosome biogenesis in eukaryotes	1.72	3.81e-2	52/108 (48.15%)	REXO5;NVL;REXO2;...
Ascorbate and aldarate metabolism	1.71	4.09e-2	15/30 (50%)	UGT2B17;UGT2B15;UGT2B28;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	6.66uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H	Show ▼

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H, 24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 10uM	6H, 24H	Show ▼