Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMHKZX1)

• Drug Name: Benzethonium Drug Info
• Synonyms: Benzethonii chloridum [INN-Latin]; Benzetonio cloruro [DCIT]; Formula 144; Inactisol; Phemerol; Phemersol chloride; Sanizol; Antiseptol (quarternary compound); Solamin; benzethonium; 10172-60-8; 1VU15B70BP; 498-77-1; BZT (VAN); CCRIS 4748; CHEMBL221753; Caswell No. 614B; Chlorure de benzethonium [INN-French]; Cloruro de benzetonio [INN-Spanish]; EINECS 204-479-9; HSDB 567; NCI-C61494; NSC 20200; NSC20200; UNII-1VU15B70BP; benzyl-dimethyl-[2-[2-[4-(1,1,3,3-tetramethylbutyl)phenoxy]ethoxy]ethyl]ammonium
• Cross-matching ID:
  PubChem CID: 2335
  ChEBI ID: CHEMBL94725
  CAS Number: CAS 10172-60-8
  INTEDE Drug ID: DR0195

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Synthesis and degradation of ketone bodies	1.76	4.12e-2	9/10 (90%)	ACAT2;HMGCS1;BDH2;...
VEGF signaling pathway	-1.67	4.40e-2	50/59 (84.75%)	MAPKAPK3;SRC;MAPK1;...
Base excision repair	-1.70	3.66e-2	29/33 (87.88%)	PARP1;POLE;POLD1;...
Bacterial invasion of epithelial cells	-1.71	3.81e-2	59/77 (76.62%)	PXN;ARPC5;RHOG;...
Asthma	-1.75	2.86e-2	25/31 (80.65%)	HLA-DPA1;HLA-DRA;HLA-DPB1;...
Prion disease	-1.75	3.18e-2	209/273 (76.56%)	PSMD7;ADRM1;SDHB;...
Mismatch repair	-1.76	3.19e-2	22/23 (95.65%)	EXO1;RPA1;POLD1;...
Aldosterone-regulated sodium reabsorption	-1.76	3.65e-2	34/37 (91.89%)	ATP1B3;MAPK1;SGK1;...
Progesterone-mediated oocyte maturation	-1.77	3.92e-2	75/100 (75%)	AURKA;ANAPC5;ANAPC1;...
Proteasome	-1.78	4.09e-2	44/46 (95.65%)	PSMA6;PSMA2;PSMA5;...
Oocyte meiosis	-1.79	3.83e-2	90/129 (69.77%)	MAPK11;CALML4;YWHAH;...
Diabetic cardiomyopathy	-1.82	2.72e-2	162/203 (79.8%)	SDHB;ATP5PD;MMP2;...
Cell cycle	-1.83	4.09e-2	110/124 (88.71%)	ANAPC5;RBX1;DBF4;...
DNA replication	-2.56	0.00e+0	34/36 (94.44%)	RPA1;POLE;MCM7;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Hide ▲