Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMHL48F)

Drug Name
ARACHIDONYL TRIFLUOROMETHYLKETONE Drug Info
Synonyms
Arachidonyl trifluoromethyl ketone; Aacocf3; arachidonyl trifluoromethyl ketone; Arachidonyltrifluoromethane; 149301-79-1; Arachidonic acid trifluoromethyl ketone; Arachidonyltrifluoromethyl Ketone; ATFMK; UNII-00XIW1CR0F; C21H31F3O; (6Z,9Z,12Z,15Z)-1,1,1-trifluorohenicosa-6,9,12,15-tetraen-2-one; 00XIW1CR0F; CHEBI:2341; CHEMBL281211; 1,1,1-Trifluoro-6Z,9Z,12Z,15Z-heneicosatetraen-2-one; 6,9,12,15-Heneicosatetraen-2-one, 1,1,1-trifluoro-, (6Z,9Z,12Z,15Z)-; 6,9,12,15-Heneicosatetraen-2-one, 1,1,1-trifluoro-, (all-Z)-; Arachidonyl trifluoromethylketone; Arachidonyltrifluoromethyl ketone
Cross-matching ID
PubChem CID
5280436
ChEBI ID
CHEMBL281211
CAS Number
CAS 149301-79-1
TTD Drug ID
D0J8TY

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ferroptosis 2.30 0.00e+0 36/41 (87.8%) HMOX1;GCLM;SLC7A11;...
Protein processing in endoplasmic reticulum 2.15 2.01e-2 127/171 (74.27%) HSPA1A;HSPA6;HSPA8;...
Proteasome 2.14 1.34e-2 44/46 (95.65%) PSMA3;PSMA7;PSMA6;...
Antigen processing and presentation 2.01 3.02e-2 60/78 (76.92%) HSPA1A;HSPA6;HSPA8;...
Mineral absorption 1.99 2.82e-2 48/60 (80%) HMOX1;FTH1;FTL;...
Prion disease 1.95 3.86e-2 209/273 (76.56%) HSPA1A;HSPA6;HSPA8;...
Estrogen signaling pathway 1.94 3.45e-2 119/137 (86.86%) HSPA1A;HSPA6;HSPA8;...
Hepatocellular carcinoma 1.78 4.81e-2 135/168 (80.36%) HMOX1;NQO1;TXNRD1;...
Synthesis and degradation of ketone bodies -1.67 3.74e-2 9/10 (90%) HMGCS2;HMGCS1;BDH1;...
TNF signaling pathway -1.69 3.31e-2 103/112 (91.96%) PIK3CB;BIRC2;CHUK;...
NF-kappa B signaling pathway -1.70 3.07e-2 90/104 (86.54%) LYN;TRIM25;GADD45A;...
p53 signaling pathway -1.70 3.28e-2 63/73 (86.3%) PMAIP1;TP53;CDK1;...
Terpenoid backbone biosynthesis -1.72 3.31e-2 18/22 (81.82%) MVD;MVK;IDI1;...
Rheumatoid arthritis -1.73 3.23e-2 78/93 (83.87%) HLA-DOA;HLA-DPB1;ATP6V0A4;...
Graft-versus-host disease -1.75 2.98e-2 32/42 (76.19%) PRF1;HLA-E;HLA-DRA;...
DNA replication -1.80 1.99e-2 34/36 (94.44%) MCM2;POLE;RFC3;...
Viral protein interaction with cytokine and cytokine re... -1.80 2.38e-2 84/100 (84%) CCL19;CCL4;TNFRSF14;...
Other types of O-glycan biosynthesis -1.80 2.73e-2 29/47 (61.7%) POMT1;POFUT2;GALNT2;...
Asthma -1.86 9.94e-3 25/31 (80.65%) HLA-DRA;MS4A2;PRG2;...
Malaria -1.93 4.97e-3 44/50 (88%) KLRK1;TGFB3;IL1B;...
Steroid biosynthesis -2.01 0.00e+0 19/20 (95%) SOAT1;CYP27B1;CYP51A1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 80uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.002uM - 80uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 80uM 6H
HT-29 CVCL_0320 Homo sapiens 0.04uM - 80uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 80uM 6H
MDST8 CVCL_1400 Homo sapiens 80uM 6H
NCI-H508 CVCL_1561 Homo sapiens 80uM 6H
SNU-1040 CVCL_5001 Homo sapiens 80uM 6H
SNU-C4 CVCL_5008 Homo sapiens 80uM 6H
SNU-C5 CVCL_5009 Homo sapiens 80uM 6H
SW480 CVCL_0546 Homo sapiens 80uM 6H
SW620 CVCL_0547 Homo sapiens 80uM 6H
SW948 CVCL_0550 Homo sapiens 80uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 80uM 6H
HT115 CVCL_1294 Homo sapiens 80uM 6H
RKO CVCL_0504 Homo sapiens 80uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 80uM 6H
SNG-M CVCL_1707 Homo sapiens 80uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 80uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 80uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 80uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.002uM - 80uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 80uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 80uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 80uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 80uM 6H
T3M-10 CVCL_1729 Homo sapiens 80uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 80uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 80uM 6H
HCC515 CVCL_5134 Homo sapiens 0.04uM - 80uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 80uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 80uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 80uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 80uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 80uM 6H
OV7 CVCL_1623 Homo sapiens 80uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 80uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 80uM 6H
RMUG-S CVCL_1666 Homo sapiens 80uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 80uM 6H
Peripheral blood
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 80uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 80uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 80uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 80uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 80uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 80uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 80uM 6H