Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMHN3PG)

Drug Name
GRT-6005 Drug Info
Synonyms
Cebranopadol; 863513-91-1; GRT6005; UNII-7GDW9S3GN3; GRT 6005; 7GDW9S3GN3; Cebranopadol [USAN:INN]; Cebranopadol (USAN/INN); Cebranopadol(GRT-6005); SCHEMBL566256; SCHEMBL154336; GTPL8866; CHEMBL3545616; CHEMBL2364605; SCHEMBL10035739; CHEMBL3962932; SCHEMBL19336241; SCHEMBL14183935; MolPort-039-063-422; BDBM177926; ZINC3950145; EX-A1095; BCP09612; BDBM50101095; BDBM50101112; AKOS032953927; AKOS025402576; AKOS025290738; DB12830; CS-1323; SB16531; NCGC00378895-01; AK170452; HY-15536; AS-35183; Centrally-acting nociceptin agonist analgesic (oral liquid, pain/diabetic neuropathy), Grunenthal; GRT 6005/06
Cross-matching ID
PubChem CID
11848225
ChEBI ID
CHEMBL3962932
CAS Number
CAS 863513-91-1
TTD Drug ID
D03TBJ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
ECM-receptor interaction 2.31 0.00e+0 80/88 (90.91%) THBS2;LAMA3;LAMA2;...
Fructose and mannose metabolism 2.26 0.00e+0 30/33 (90.91%) ALDOC;AKR1B10;PFKFB3;...
p53 signaling pathway 2.21 0.00e+0 63/73 (86.3%) CDKN1A;DDB2;SESN1;...
Primary immunodeficiency 1.96 1.06e-2 33/38 (86.84%) RFX5;TAP1;IL7R;...
Glycolysis / Gluconeogenesis 1.90 8.49e-3 56/67 (83.58%) ADH1B;ALDOC;ENO2;...
Systemic lupus erythematosus 1.83 2.12e-2 45/135 (33.33%) C3;C1R;C7;...
Pentose phosphate pathway 1.83 1.82e-2 25/30 (83.33%) ALDOC;PFKM;FBP1;...
Graft-versus-host disease 1.78 2.79e-2 32/42 (76.19%) IL1B;FAS;HLA-DPA1;...
Intestinal immune network for IgA production 1.76 3.42e-2 38/48 (79.17%) ITGB7;HLA-DPA1;CXCL12;...
Focal adhesion 1.74 3.50e-2 180/201 (89.55%) THBS2;LAMA3;LAMA2;...
Type I diabetes mellitus 1.73 3.67e-2 38/43 (88.37%) CPE;IL1B;FAS;...
Malaria 1.73 3.36e-2 44/50 (88%) THBS2;IL1B;THBS4;...
Asthma 1.73 3.27e-2 25/31 (80.65%) HLA-DPA1;HLA-DMB;CD40;...
Allograft rejection 1.72 3.11e-2 32/38 (84.21%) FAS;HLA-DPA1;HLA-DMB;...
Small cell lung cancer 1.71 3.82e-2 90/92 (97.83%) CDKN1A;DDB2;LAMA3;...
Complement and coagulation cascades 1.70 3.71e-2 76/85 (89.41%) C3;C1R;PROCR;...
Starch and sucrose metabolism 1.69 4.18e-2 25/36 (69.44%) GAA;GBE1;GYS1;...
Viral myocarditis 1.68 4.07e-2 53/60 (88.33%) LAMA2;DMD;HLA-DPA1;...
Type II diabetes mellitus 1.67 4.25e-2 42/46 (91.3%) SOCS1;IRS1;ADIPOQ;...
Staphylococcus aureus infection 1.65 4.72e-2 72/95 (75.79%) C3;C1R;CFI;...
Arachidonic acid metabolism 1.65 4.50e-2 48/61 (78.69%) GPX3;PTGIS;PLA2G2A;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 24H