Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMHQRYE)

Drug Name
Tenidap Drug Info
Cross-matching ID
PubChem CID
60712
ChEBI ID
CHEMBL35847
CAS Number
CAS 120210-48-2
TTD Drug ID
D02RQT
VARIDT Drug ID
DR01162

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome biogenesis in eukaryotes 2.14 0.00e+0 52/108 (48.15%) NVL;RBM28;IMP3;...
Fanconi anemia pathway 2.04 3.04e-3 36/54 (66.67%) REV3L;FANCI;FAAP100;...
Cell cycle 1.97 4.05e-3 110/124 (88.71%) CDC20;MCM3;DBF4;...
Type II diabetes mellitus 1.86 1.37e-2 42/46 (91.3%) SOCS1;ABCC8;MAPK1;...
DNA replication 1.82 1.22e-2 34/36 (94.44%) MCM3;POLE2;MCM6;...
Fatty acid biosynthesis 1.77 2.03e-2 16/18 (88.89%) ACSL1;ACSL3;MCAT;...
RNA polymerase 1.73 2.26e-2 23/31 (74.19%) POLR1C;POLR2F;POLR3G;...
Nicotine addiction 1.70 3.19e-2 32/40 (80%) GABRP;GABRE;GABRA2;...
B cell receptor signaling pathway -1.66 4.73e-2 71/81 (87.65%) PIK3CD;MAP2K2;GRB2;...
Fluid shear stress and atherosclerosis -1.67 4.28e-2 123/139 (88.49%) MAP3K5;MAP2K5;PDGFA;...
Asthma -1.68 4.11e-2 25/31 (80.65%) HLA-DOA;HLA-DRA;HLA-DRB1;...
Th17 cell differentiation -1.68 4.31e-2 95/107 (88.79%) STAT5A;GATA3;HSP90AA1;...
Inflammatory bowel disease -1.69 4.33e-2 58/65 (89.23%) STAT4;TLR5;GATA3;...
Hematopoietic cell lineage -1.70 3.91e-2 90/99 (90.91%) CD5;HLA-DOA;CD8B;...
Collecting duct acid secretion -1.76 2.32e-2 22/27 (81.48%) CLCNKB;CA2;ATP6V1B1;...
Mineral absorption -1.77 2.28e-2 48/60 (80%) MT1X;FTL;SLC5A1;...
Cell adhesion molecules -1.81 1.64e-2 118/148 (79.73%) HLA-DOA;SELPLG;NRXN2;...
Leishmaniasis -1.83 1.51e-2 67/77 (87.01%) MAP3K7;FCGR2A;ITGB1;...
Intestinal immune network for IgA production -1.84 1.53e-2 38/48 (79.17%) HLA-DOA;IL15;HLA-DRA;...
Osteoclast differentiation -1.85 1.56e-2 117/127 (92.13%) FOSL2;LILRA2;FOSL1;...
Leukocyte transendothelial migration -1.85 1.88e-2 90/114 (78.95%) ITGB1;PIK3CD;GNAI3;...
Allograft rejection -1.87 2.35e-2 32/38 (84.21%) HLA-A;PRF1;HLA-DOA;...
Graft-versus-host disease -1.90 2.68e-2 32/42 (76.19%) KLRD1;IL1B;HLA-A;...
Phagosome -1.91 3.35e-2 118/152 (77.63%) CLEC4M;ATP6V1H;SEC61G;...
Rheumatoid arthritis -2.20 0.00e+0 78/93 (83.87%) ATP6V1F;ATP6V0E1;ATP6V0A4;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 2.22uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.03uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H