Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMHR8KW)

• Drug Name: Alvimopan Drug Info
• Synonyms: Alvimopan anhydrous; LY 246736; LY246736; Adl 8-2698; Entereg (TN); Trans-3,4-dimethyl-4-(3-hydroxyphenyl) piperidine; Glycine, N-[2-[[4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl; 2-[[(2S)-2-benzyl-3-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]propanoyl]amino]acetic acid
• Therapeutic Class: Analgesics
• Cross-matching ID:
  PubChem CID: 5488548
  ChEBI ID: CHEMBL270190
  CAS Number: CAS 156053-89-3
  TTD Drug ID: D0D7KC
  ACDINA Drug ID: D00026

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Notch signaling pathway	1.88	4.16e-2	49/59 (83.05%)	CTBP2;HEY2;NOTCH1;...
Toxoplasmosis	-1.65	4.87e-2	103/112 (91.96%)	MAPK1;IRAK4;GNAI2;...
Primary immunodeficiency	-1.66	4.85e-2	33/38 (86.84%)	CD8A;LCK;IKBKG;...
Autophagy	-1.66	4.65e-2	113/169 (66.86%)	PIK3CA;RB1CC1;HMGB1;...
Hematopoietic cell lineage	-1.70	3.26e-2	90/99 (90.91%)	CD1B;HLA-DPA1;FLT3LG;...
Synaptic vesicle cycle	-1.70	3.35e-2	63/78 (80.77%)	ATP6V0B;SLC18A2;SLC6A4;...
Shigellosis	-1.71	3.18e-2	180/246 (73.17%)	NFKBIA;PIK3CA;MAPK11;...
Vibrio cholerae infection	-1.71	3.13e-2	44/50 (88%)	PRKACB;ATP6V0B;TJP1;...
Phosphonate and phosphinate metabolism	-1.73	2.63e-2	5/6 (83.33%)	CHPT1
Galactose metabolism	-1.73	2.78e-2	26/31 (83.87%)	MGAM;HK3;UGP2;...
Fluid shear stress and atherosclerosis	-1.74	2.87e-2	123/139 (88.49%)	IL1B;GSTP1;NCF2;...
Th17 cell differentiation	-1.74	3.07e-2	95/107 (88.79%)	PLCG1;IL1R1;RARA;...
Nitrogen metabolism	-1.74	3.19e-2	16/17 (94.12%)	CA5A;CA7;CA5B;...
Antigen processing and presentation	-1.75	3.12e-2	60/78 (76.92%)	CD8A;HSPA1L;HSPA5;...
Leishmaniasis	-1.75	3.38e-2	67/77 (87.01%)	NFKBIA;MAPK11;JUN;...
Osteoclast differentiation	-1.76	3.44e-2	117/127 (92.13%)	NFKBIA;PIK3CA;MAPK11;...
Phagosome	-1.77	3.25e-2	118/152 (77.63%)	CYBB;HLA-E;ATP6V0B;...
Ferroptosis	-1.80	2.40e-2	36/41 (87.8%)	PCBP1;VDAC2;TF;...
Fructose and mannose metabolism	-1.81	2.20e-2	30/33 (90.91%)	HK3;ALDOA;PFKFB3;...
Glycolysis / Gluconeogenesis	-1.83	2.13e-2	56/67 (83.58%)	ENO1;ADH5;PKM;...
Staphylococcus aureus infection	-1.86	1.58e-2	72/95 (75.79%)	HLA-DPA1;KRT18;FCGR2A;...
Lysosome	-1.86	1.89e-2	115/128 (89.84%)	CTSV;MANBA;CLTC;...
Tuberculosis	-1.92	1.35e-2	159/180 (88.33%)	HSPD1;BID;FCGR2A;...
Glutathione metabolism	-1.98	0.00e+0	43/57 (75.44%)	GSTP1;IDH1;GSTM4;...
Pentose phosphate pathway	-2.04	0.00e+0	25/30 (83.33%)	RBKS;G6PD;GPI;...
Collecting duct acid secretion	-2.08	0.00e+0	22/27 (81.48%)	ATP6V0E1;ATP6V1E1;ATP6V1A;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	0.12uM - 10uM	6H, 24H, 48H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.03uM - 10uM	6H, 24H, 48H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H, 48H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H	Show ▼