Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMHTPSF)

Drug Name
PNU-22394 Drug Info
Synonyms
PNU-22394; CHEMBL6557; 6-methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole; 6-Methyl-1,2,3,4,5,6-hexahydro-azepino[4,5-b]indole; AC1L1DHJ; SCHEMBL5364550; CHEBI:92297; ZINC2018607; BDBM50130095; BRD-K16551401-003-02-6; BRD-K16551401-003-01-8; 6-methyl-2,3,4,5-tetrahydro-1H-azepino[4,5-b]indole
Cross-matching ID
PubChem CID
27559
ChEBI ID
CHEMBL6557
CAS Number
CAS 15923-78-1
TTD Drug ID
D04QRS

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Progesterone-mediated oocyte maturation 2.19 0.00e+0 75/100 (75%) PRKACB;ADCY2;CCNA2;...
Cell cycle 2.14 0.00e+0 110/124 (88.71%) CDC20;CCNA2;MCM7;...
Nucleotide excision repair 2.11 0.00e+0 40/47 (85.11%) RAD23B;RFC3;RFC5;...
DNA replication 2.05 0.00e+0 34/36 (94.44%) MCM7;RFC3;RFC5;...
Oocyte meiosis 1.98 2.56e-3 90/129 (69.77%) CDC20;PRKACB;ADCY2;...
Mismatch repair 1.82 1.49e-2 22/23 (95.65%) RFC3;EXO1;RFC5;...
Neutrophil extracellular trap formation -1.90 3.56e-2 101/189 (53.44%) MAPK3;SIGLEC9;TLR7;...
Staphylococcus aureus infection -2.01 6.67e-3 72/95 (75.79%) KRT19;KRT24;FCGR2A;...
Complement and coagulation cascades -2.03 1.33e-2 76/85 (89.41%) CFHR2;CFHR4;SERPING1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H