Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMHYLQ2)

Drug Name
Lithium chloride Drug Info
Synonyms
LITHIUM CHLORIDE; 7447-41-8; Lithiumchloride; Lithium chloride (LiCl); LiCl; chlorure de lithium; Chlorku litu; chlorolithium; Lithiumchlorid; Chlorku litu [Polish]; Luthium chloride; Chlorure de lithium [French]; CCRIS 5924; UNII-G4962QA067; HSDB 4281; EINECS 231-212-3; lithium(1+) ion chloride; NSC 327172; CHEMBL69710; CHEBI:48607; NSC327172; MFCD00011078; G4962QA067; Lithium chloride, 99%, extra pure; ClLi; Lithium chloride, 99+%, ACS reagent; Lithium chloride, 99%, for molecular biology; Lithium chloride, 99%, for analysis, anhyd
Cross-matching ID
PubChem CID
433294
ChEBI ID
CHEMBL69710
CAS Number
CAS 7447-41-8
TTD Drug ID
D07WXT

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.49 0.00e+0 34/36 (94.44%) MCM5;LIG1;FEN1;...
Spliceosome 2.29 0.00e+0 101/150 (67.33%) HSPA1A;HNRNPM;CHERP;...
RNA transport 2.06 3.47e-3 128/186 (68.82%) EIF4G1;NUP85;TACC3;...
Ribosome biogenesis in eukaryotes 2.05 2.60e-3 52/108 (48.15%) DKC1;PWP2;LSG1;...
Cell cycle 2.04 2.08e-3 110/124 (88.71%) MCM5;CCND2;ESPL1;...
Mismatch repair 1.94 3.47e-3 22/23 (95.65%) LIG1;RFC3;MSH2;...
Basal cell carcinoma 1.90 7.43e-3 41/63 (65.08%) DDB2;DVL3;BMP4;...
Parathyroid hormone synthesis, secretion and action 1.74 3.12e-2 98/106 (92.45%) GNAS;PDE4B;NR4A2;...
Toxoplasmosis 1.71 3.93e-2 103/112 (91.96%) HSPA1A;ITGA6;CD40;...
Epstein-Barr virus infection 1.68 4.99e-2 189/202 (93.56%) DDB2;CCND2;NCOR2;...
Terpenoid backbone biosynthesis -1.71 3.63e-2 18/22 (81.82%) GGPS1;PMVK;MVD;...
Cardiac muscle contraction -1.72 3.62e-2 64/87 (73.56%) TPM3;COX8A;MYH7;...
Biosynthesis of unsaturated fatty acids -1.72 3.77e-2 21/27 (77.78%) HACD1;HSD17B12;FADS2;...
Fatty acid elongation -1.78 2.12e-2 19/27 (70.37%) ECHS1;ACAA2;PPT1;...
Tryptophan metabolism -1.79 2.25e-2 35/42 (83.33%) DHTKD1;TDO2;HAAO;...
Pentose and glucuronate interconversions -1.84 1.57e-2 17/34 (50%) CRYL1;UGP2;AKR1A1;...
Folate biosynthesis -1.84 1.79e-2 23/26 (88.46%) PAH;PCBD1;GCH1;...
Steroid hormone biosynthesis -2.02 0.00e+0 43/61 (70.49%) HSD11B2;AKR1D1;HSD11B1;...
Metabolism of xenobiotics by cytochrome P450 -2.05 0.00e+0 49/77 (63.64%) GSTK1;ADH5;ALDH3B1;...
Peroxisome -2.06 0.00e+0 72/82 (87.8%) CRAT;ACAA1;ACSL1;...
Histidine metabolism -2.08 0.00e+0 16/22 (72.73%) ALDH3B1;HAL;ASPA;...
Oxidative phosphorylation -2.26 0.00e+0 93/133 (69.92%) NDUFB2;ATP6V1D;NDUFA8;...
Steroid biosynthesis -2.34 0.00e+0 19/20 (95%) LSS;FDFT1;MSMO1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H