Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMI25N2)

Drug Name
Pyrvinium pamoate Drug Info
Synonyms
Pyrvinium embonate; Pyrvinium pamoate (JAN/USP); Pyrvinium pamoate salt hydrate; SCHEMBL62130; Vanquil; Vanquin; Vermitibier; Viprynium embonate; Vipyrvinium embonate; CAS-3546-41-6; CHEBI:8688; CHEMBL1908377; DSSTox_CID_3545; DSSTox_GSID_23545; DSSTox_RID_77072; Dipyrivinium Pamoate; NCGC00017042-01; NSC 223622; Povan (TN)
Cross-matching ID
PubChem CID
54680693
ChEBI ID
CHEMBL8688
CAS Number
CAS 3546-41-6
TTD Drug ID
D0K9QQ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
TNF signaling pathway 2.39 0.00e+0 103/112 (91.96%) PTGS2;NFKBIA;TNFAIP3;...
Chronic myeloid leukemia 2.29 0.00e+0 72/76 (94.74%) CDKN1A;GADD45A;NFKBIA;...
Graft-versus-host disease 2.19 0.00e+0 32/42 (76.19%) FAS;IL6;IL1A;...
C-type lectin receptor signaling pathway 2.13 0.00e+0 93/104 (89.42%) PTGS2;NFKBIA;RELB;...
NF-kappa B signaling pathway 2.09 0.00e+0 90/104 (86.54%) CXCL8;GADD45A;PTGS2;...
Kaposi sarcoma-associated herpesvirus infection 2.07 0.00e+0 172/193 (89.12%) CDKN1A;CXCL8;PTGS2;...
Melanoma 2.07 0.00e+0 68/72 (94.44%) CDKN1A;GADD45A;PDGFA;...
Basal cell carcinoma 2.06 0.00e+0 41/63 (65.08%) CDKN1A;GADD45A;DDB2;...
Prostate cancer 2.03 0.00e+0 93/97 (95.88%) CDKN1A;NFKBIA;PDGFA;...
JAK-STAT signaling pathway 2.03 0.00e+0 146/162 (90.12%) CDKN1A;PDGFA;LIF;...
Small cell lung cancer 1.98 0.00e+0 90/92 (97.83%) CDKN1A;GADD45A;PTGS2;...
Osteoclast differentiation 1.98 0.00e+0 117/127 (92.13%) FOSL1;NFKBIA;RELB;...
NOD-like receptor signaling pathway 1.91 7.84e-4 145/181 (80.11%) CXCL8;NFKBIA;TNFAIP3;...
Pancreatic cancer 1.91 7.28e-4 75/76 (98.68%) CDKN1A;GADD45A;DDB2;...
Transcriptional misregulation in cancer 1.89 1.36e-3 158/192 (82.29%) CDKN1A;CXCL8;DUSP6;...
MAPK signaling pathway 1.88 1.27e-3 272/294 (92.52%) DUSP6;GADD45A;AREG;...
Bladder cancer 1.88 1.80e-3 40/41 (97.56%) CDKN1A;CXCL8;HBEGF;...
Toll-like receptor signaling pathway 1.87 1.70e-3 94/104 (90.38%) CXCL8;NFKBIA;TICAM1;...
Cytokine-cytokine receptor interaction 1.87 1.61e-3 246/295 (83.39%) CXCL8;TNFRSF10B;GDF15;...
Necroptosis 1.85 2.55e-3 113/159 (71.07%) TNFRSF10B;TNFAIP3;FAS;...
MicroRNAs in cancer 1.84 2.91e-3 146/310 (47.1%) CDKN1A;DDIT4;PTGS2;...
Mitophagy 1.84 2.78e-3 56/68 (82.35%) ATF4;TP53;BCL2L1;...
Circadian rhythm 1.84 2.66e-3 26/31 (83.87%) BHLHE41;PER2;BHLHE40;...
Viral myocarditis 1.83 3.40e-3 53/60 (88.33%) CD55;CXADR;ICAM1;...
Glioma 1.81 4.89e-3 67/75 (89.33%) CDKN1A;GADD45A;PDGFA;...
IL-17 signaling pathway 1.80 5.10e-3 84/94 (89.36%) FOSL1;CXCL8;PTGS2;...
Autoimmune thyroid disease 1.79 5.66e-3 46/53 (86.79%) FAS;HLA-B;CD86;...
p53 signaling pathway 1.79 5.46e-3 63/73 (86.3%) CDKN1A;SESN1;GADD45A;...
Pathogenic Escherichia coli infection 1.78 5.78e-3 152/197 (77.16%) CXCL8;ARHGEF2;TNFRSF10B;...
Epithelial cell signaling in Helicobacter pylori infect... 1.77 5.59e-3 62/70 (88.57%) CXCL8;NFKBIA;CXCL2;...
Propanoate metabolism -1.64 4.52e-2 30/34 (88.24%) HADHA;SUCLG1;ACAT1;...
Fatty acid biosynthesis -1.64 4.61e-2 16/18 (88.89%) OXSM;ACSL6;MECR;...
Amino sugar and nucleotide sugar metabolism -1.67 3.73e-2 38/48 (79.17%) GMPPA;UGDH;HK1;...
PPAR signaling pathway -1.67 3.90e-2 66/74 (89.19%) CPT1A;APOC3;FABP3;...
Steroid hormone biosynthesis -1.69 3.25e-2 43/61 (70.49%) SRD5A3;HSD17B7;UGT2A3;...
Fanconi anemia pathway -1.70 3.41e-2 36/54 (66.67%) FAAP100;BRCA1;MLH1;...
Aminoacyl-tRNA biosynthesis -1.73 2.18e-2 15/66 (22.73%) CARS2;NARS2;GATC;...
Pyruvate metabolism -1.73 2.19e-2 41/47 (87.23%) DLAT;ADH1B;ACAT2;...
Pentose phosphate pathway -1.75 2.22e-2 25/30 (83.33%) RGN;PFKL;PGM1;...
Glycolysis / Gluconeogenesis -1.80 9.75e-3 56/67 (83.58%) DLAT;ADH1B;PCK1;...
Steroid biosynthesis -1.80 1.08e-2 19/20 (95%) NSDHL;LIPA;TM7SF2;...
Terpenoid backbone biosynthesis -1.82 8.53e-3 18/22 (81.82%) ACAT2;FNTB;ICMT;...
Mismatch repair -1.88 2.79e-3 22/23 (95.65%) POLD2;EXO1;POLD1;...
Starch and sucrose metabolism -1.92 1.63e-3 25/36 (69.44%) HK1;PYGL;SI;...
Bile secretion -1.93 1.95e-3 68/90 (75.56%) ABCC2;ABCB4;PRKACA;...
DNA replication -1.95 2.44e-3 34/36 (94.44%) RNASEH2B;POLA2;MCM5;...
Cell cycle -2.03 0.00e+0 110/124 (88.71%) MCM5;ORC6;MCM2;...
Oocyte meiosis -2.18 0.00e+0 90/129 (69.77%) PRKACA;PPP3CB;ADCY2;...
Progesterone-mediated oocyte maturation -2.46 0.00e+0 75/100 (75%) PIK3R2;AKT2;ADCY9;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.37uM - 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 10uM 6H
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 10uM 6H
MDST8 CVCL_1400 Homo sapiens 10uM 6H
NCI-H508 CVCL_1561 Homo sapiens 10uM 6H
SNU-1040 CVCL_5001 Homo sapiens 10uM 6H
SNU-C4 CVCL_5008 Homo sapiens 10uM 6H
SNU-C5 CVCL_5009 Homo sapiens 10uM 6H
SW480 CVCL_0546 Homo sapiens 10uM 6H
SW620 CVCL_0547 Homo sapiens 10uM 6H
SW948 CVCL_0550 Homo sapiens 10uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 10uM 6H
HT115 CVCL_1294 Homo sapiens 10uM 6H
RKO CVCL_0504 Homo sapiens 10uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 10uM 6H
SNG-M CVCL_1707 Homo sapiens 10uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 10uM 6H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 10uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 10uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 10uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 10uM 6H
T3M-10 CVCL_1729 Homo sapiens 10uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 10uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 10uM 6H
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 10uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 10uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 10uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 10uM 6H
OV7 CVCL_1623 Homo sapiens 10uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 10uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 10uM 6H
RMUG-S CVCL_1666 Homo sapiens 10uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 10uM 6H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 10uM 6H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 10uM 6H
PL-21 CVCL_2161 Homo sapiens 10uM 6H
SKM-1 CVCL_0010 Homo sapiens 10uM 6H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 0.37uM - 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H
SK-MEL-1 CVCL_0523 Homo sapiens 10uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 10uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 10uM 6H