Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMI2GSK)

Drug Name
Coluracetam Drug Info
Synonyms
BCI-540; MKC-231; High-affinity choline uptake facilitator (CNS disorders), Mitsubishi; Neurons growth promoting compound (major depressive disorder/anxiety), BrainCells; High-affinity choline uptake facilitator (depression/ anxiety), BrainCells
Cross-matching ID
PubChem CID
214346
CAS Number
CAS 135463-81-9
TTD Drug ID
D01MHI

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Metabolism of xenobiotics by cytochrome P450 2.29 0.00e+0 49/77 (63.64%) EPHX1;ALDH3A1;GSTO1;...
Ribosome 2.10 0.00e+0 113/158 (71.52%) RPS5;RPL36;RPL35;...
Glycolysis / Gluconeogenesis 1.91 1.02e-2 56/67 (83.58%) GAPDH;ALDH2;PKM;...
TGF-beta signaling pathway 1.91 7.62e-3 81/94 (86.17%) ID4;ID3;ID1;...
Mismatch repair 1.90 9.15e-3 22/23 (95.65%) MLH1;RPA3;RPA2;...
Retinol metabolism 1.76 4.45e-2 41/68 (60.29%) DHRS3;ALDH1A1;ALDH1A3;...
GnRH signaling pathway -1.68 4.43e-2 80/93 (86.02%) MAP2K4;MAPK10;PLCB4;...
Taurine and hypotaurine metabolism -1.70 3.57e-2 8/11 (72.73%) GGT5;CSAD;ADO;...
Protein digestion and absorption -1.71 3.16e-2 78/103 (75.73%) PRSS3;COL17A1;COL5A3;...
GnRH secretion -1.72 3.21e-2 60/64 (93.75%) PLCB4;CACNA1G;HRAS;...
Endocrine and other factor-regulated calcium reabsorpti... -1.73 2.98e-2 49/53 (92.45%) AP2B1;DNM3;PLCB4;...
alpha-Linolenic acid metabolism -1.74 2.73e-2 17/25 (68%) PLA2G12A;PLA2G1B;PLA2G4A;...
Glutamatergic synapse -1.74 2.74e-2 97/114 (85.09%) SLC1A2;GRM1;GNG3;...
Ovarian steroidogenesis -1.75 2.76e-2 41/51 (80.39%) IGF1R;INSR;PLA2G4C;...
Viral myocarditis -1.77 1.65e-2 53/60 (88.33%) CD86;HLA-DOB;EIF4G3;...
Spinocerebellar ataxia -1.79 1.69e-2 128/143 (89.51%) PSMD6;VDAC3;PSMD14;...
Glycerophospholipid metabolism -1.80 1.90e-2 71/98 (72.45%) PTDSS2;ACHE;LCAT;...
Toxoplasmosis -1.80 1.99e-2 103/112 (91.96%) BCL2L1;JAK1;MAPK10;...
Carbohydrate digestion and absorption -1.82 1.69e-2 37/47 (78.72%) PLCB4;HK2;PIK3R1;...
Aldosterone synthesis and secretion -1.82 2.03e-2 85/98 (86.73%) CREB5;DAGLA;CYP21A2;...
Insulin secretion -1.85 1.90e-2 75/86 (87.21%) ABCC8;GLP1R;ATF6B;...
Nicotine addiction -1.88 2.11e-2 32/40 (80%) GABRA3;GABRA4;GABRA6;...
Estrogen signaling pathway -2.02 0.00e+0 119/137 (86.86%) FKBP5;HSPA1A;PLCB4;...
Staphylococcus aureus infection -2.05 0.00e+0 72/95 (75.79%) C1R;HLA-DOB;ITGB2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H