Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMI2QPE)

• Drug Name: Didanosine Drug Info
• Synonyms: didanosine; 69655-05-6; DIDEOXYINOSINE; Videx; Videx EC; Inosine, 2',3'-dideoxy-; ddIno; Didanosina; Didanosinum; DDI; BMY-40900; UNII-K3GDH6OH08; K3GDH6OH08; Didanosinum [INN-Latin]; Didanosina [INN-Spanish]; CHEBI:490877; 9-(2,3-Dideoxy-beta-D-ribofuranosyl)-6-oxopurine; NSC 612049; 9-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,9-dihydro-6H-purin-6-one; 9-[(2R,5R)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-2-YL]-1,9-DIHYDRO-6H-PURIN-6-ONE; NCGC00159514-02; NCGC00090691-03; DRG-0016; BMY 40900; DSSTox_CID_2927
• Therapeutic Class: Anti-HIV Agents
• Cross-matching ID:
  PubChem CID: 135398739
  ChEBI ID: CHEMBL490877
  CAS Number: CAS 69655-05-6
  TTD Drug ID: D06FDR
  VARIDT Drug ID: DR01175
  ACDINA Drug ID: D00195

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Primary bile acid biosynthesis	2.00	8.76e-3	15/17 (88.24%)	CYP27A1;HSD17B4;SLC27A5;...
ECM-receptor interaction	1.95	1.31e-2	80/88 (90.91%)	FN1;LAMA4;LAMA3;...
Autoimmune thyroid disease	1.90	2.04e-2	46/53 (86.79%)	HLA-DPB1;HLA-DQA1;CD40;...
Allograft rejection	1.89	1.53e-2	32/38 (84.21%)	HLA-DPB1;HLA-DQA1;CD40;...
Complement and coagulation cascades	1.89	1.23e-2	76/85 (89.41%)	A2M;C1R;C1QB;...
Phagosome	1.81	2.19e-2	118/152 (77.63%)	TLR4;C1R;SFTPA2;...
Systemic lupus erythematosus	1.78	2.75e-2	45/135 (33.33%)	C1R;HLA-DPB1;HLA-DQA1;...
Fanconi anemia pathway	1.76	2.52e-2	36/54 (66.67%)	FANCL;BLM;FANCG;...
Pantothenate and CoA biosynthesis	1.75	2.82e-2	14/21 (66.67%)	BCAT2;DPYD;BCAT1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H	Hide ▲

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H	Show ▼

Liver

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	15uM	72H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 10uM	6H, 24H	Show ▼