Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMI36WC)

Drug Name
1,4-Diethylene Dioxide Drug Info
Synonyms
1,4-DIOXANE; Dioxane; 123-91-1; p-Dioxane; 1,4-Diethylene dioxide; Diethylene ether; Dioxan; 1,4-Dioxacyclohexane; Dioxanne; Tetrahydro-p-dioxin; Di(ethylene oxide); Tetrahydro-1,4-dioxin; Dioxane-1,4; Diethylene dioxide; Glycol ethylene ether; 1,4-Dioxan; p-Dioxan; Dioxan-1,4; Dioxyethylene ether; Dioksan; Diokan; para-Dioxane; Tetrahydro-para-dioxin; Diossano-1,4; Dioxaan-1,4; p-Dioxin, tetrahydro-; Glycolethylenether; Dioksan [Polish]; Dioxanne [French]; RCRA waste number U108; p-Dioxan [Czech]; 1,4-Dioxanne; NCI-C03689
Cross-matching ID
PubChem CID
31275
ChEBI ID
CHEMBL47032
CAS Number
CAS 123-91-1
TTD Drug ID
D08AMH

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Staphylococcus aureus infection 2.21 0.00e+0 72/95 (75.79%) FGG;KRT14;CFB;...
Complement and coagulation cascades 2.10 0.00e+0 76/85 (89.41%) A2M;FGG;CFB;...
Oxidative phosphorylation 1.82 4.01e-2 93/133 (69.92%) ATP6V0E2;NDUFA1;NDUFS7;...
Fatty acid degradation 1.81 3.28e-2 40/43 (93.02%) ADH1B;ADH1C;ALDH2;...
PPAR signaling pathway 1.75 4.38e-2 66/74 (89.19%) APOA2;HMGCS2;APOC3;...
Bladder cancer 1.75 3.83e-2 40/41 (97.56%) MMP9;FGFR3;CDH1;...
Systemic lupus erythematosus 1.71 4.85e-2 45/135 (33.33%) HLA-DQA1;FCGR3B;C1S;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 20uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 20uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 1.25uM - 40uM 3H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 20uM 6H, 24H