Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMI3GIA)

Drug Name
F10 Drug Info
Synonyms
F10 (neutralizing antibody, group 1 influenza A infection); F10 (neutralizing antibody, group 1 influenza A infection), Harvard Medical School/Dana-Farber Cancer Institute/XOMA/SRI International; F10 (neutralizing antibody, H5N1/H1N1 infection), Harvard Medical School/Dana-Farber Cancer Institute/XOMA/SRI International
Cross-matching ID
PubChem CID
5943
ChEBI ID
CHEMBL44814
CAS Number
CAS 56-23-5
TTD Drug ID
D0L9PX

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
mRNA surveillance pathway 2.06 0.00e+0 71/98 (72.45%) GSPT2;GSPT1;PPP2R1A;...
Steroid biosynthesis 2.04 5.21e-3 19/20 (95%) SC5D;SQLE;DHCR24;...
Spliceosome 1.93 1.04e-2 101/150 (67.33%) HSPA8;SRSF1;SF3B1;...
RNA transport 1.86 1.56e-2 128/186 (68.82%) EIF5;SUMO3;EIF2S3;...
Selenocompound metabolism -1.62 4.41e-2 11/17 (64.71%) SEPHS2;SCLY;PAPSS1;...
Fluid shear stress and atherosclerosis -1.63 4.16e-2 123/139 (88.49%) MAPK10;TXN;PDGFA;...
Histidine metabolism -1.64 4.12e-2 16/22 (72.73%) ALDH3A1;ALDH9A1;AOC1;...
Complement and coagulation cascades -1.67 3.01e-2 76/85 (89.41%) F3;C4BPA;MBL2;...
Drug metabolism -1.69 2.48e-2 78/151 (51.66%) CES2;GSTM4;CYP2B6;...
Ascorbate and aldarate metabolism -1.70 2.34e-2 15/30 (50%) AKR1A1;RGN;ALDH9A1;...
Arachidonic acid metabolism -1.70 2.30e-2 48/61 (78.69%) CBR3;CYP2B6;CYP2C9;...
Steroid hormone biosynthesis -1.73 1.62e-2 43/61 (70.49%) CYP1A2;AKR1C4;CYP11A1;...
Tyrosine metabolism -1.74 1.59e-2 30/36 (83.33%) ALDH3A1;DDC;PNMT;...
Autoimmune thyroid disease -1.75 1.64e-2 46/53 (86.79%) PRF1;HLA-DQB1;GZMB;...
Folate biosynthesis -1.75 1.70e-2 23/26 (88.46%) AKR1B1;GCH1;PAH;...
Ether lipid metabolism -1.75 1.85e-2 32/49 (65.31%) PLA2G6;GAL3ST1;PLA2G1B;...
Cell adhesion molecules -1.79 1.46e-2 118/148 (79.73%) HLA-DQB1;ICAM2;SELP;...
Retinol metabolism -1.82 1.29e-2 41/68 (60.29%) CYP1A2;CYP2W1;CYP2C18;...
Other glycan degradation -1.85 9.70e-3 13/18 (72.22%) MAN2C1;MAN2B2;NEU1;...
Pentose and glucuronate interconversions -1.89 8.32e-3 17/34 (50%) UGT2B15;SORD;GUSB;...
Allograft rejection -1.97 3.23e-3 32/38 (84.21%) PRF1;HLA-DQB1;GZMB;...
Mineral absorption -2.03 1.94e-3 48/60 (80%) HEPH;MT2A;ATP2B1;...
Metabolism of xenobiotics by cytochrome P450 -2.03 2.43e-3 49/77 (63.64%) GSTM4;CBR3;CYP2B6;...
Rheumatoid arthritis -2.08 0.00e+0 78/93 (83.87%) TLR2;LTB;HLA-DQB1;...
Type I diabetes mellitus -2.08 0.00e+0 38/43 (88.37%) PRF1;HLA-DQB1;GZMB;...
Graft-versus-host disease -2.10 0.00e+0 32/42 (76.19%) PRF1;HLA-DQB1;GZMB;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 10uM - 100uM 48H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 1.25uM - 100uM 3H, 24H, 48H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H