Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMI4WVE)

Drug Name
CPCCOEt Drug Info
Synonyms
CHEMBL327783; 179067-99-3; AC1O3E8H; 7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxylate ethyl ester; SCHEMBL12648369; MolPort-003-940-874; CPCCOEt, > AKOS024456339; LP00300; NCGC00024948-02; KB-49121; AS-16761; L000202; SR-01000597466; SR-01000597466-1; BRD-A05729358-001-01-2; ethyl (7E)-7-hydroxyimino-1,7a-dihydrocyclopropa[b]chromene-1a-carboxylate
Cross-matching ID
PubChem CID
6278000
ChEBI ID
CHEMBL327783
TTD Drug ID
D01EVA

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Nicotinate and nicotinamide metabolism -1.67 4.87e-2 25/35 (71.43%) ENPP1;SIRT2;QPRT;...
IL-17 signaling pathway -1.70 3.87e-2 84/94 (89.36%) CSF3;MMP9;IL17RA;...
Butanoate metabolism -1.71 3.85e-2 23/28 (82.14%) HMGCS2;ACSM3;AACS;...
Caffeine metabolism -1.72 3.97e-2 5/6 (83.33%) CYP1A2;NAT1
Cardiac muscle contraction -1.73 4.03e-2 64/87 (73.56%) CACNB4;MYH7;ATP1A3;...
Biosynthesis of unsaturated fatty acids -1.77 2.80e-2 21/27 (77.78%) HSD17B4;ACAA1;ELOVL4;...
Synthesis and degradation of ketone bodies -1.82 7.34e-3 9/10 (90%) ACAT2;HMGCS1
Legionellosis -1.82 8.39e-3 51/57 (89.47%) TLR2;ARF1;RAB1A;...
Pertussis -1.86 9.79e-3 64/76 (84.21%) C1R;CASP1;IL1A;...
Complement and coagulation cascades -1.96 1.68e-3 76/85 (89.41%) CFH;KLKB1;SERPINB2;...
Ferroptosis -1.99 2.10e-3 36/41 (87.8%) ACSL4;CP;MAP1LC3B;...
Staphylococcus aureus infection -2.09 0.00e+0 72/95 (75.79%) PLG;MBL2;C1R;...
Terpenoid backbone biosynthesis -2.15 0.00e+0 18/22 (81.82%) HMGCS2;MVD;MVK;...
Steroid biosynthesis -2.44 0.00e+0 19/20 (95%) LSS;FDFT1;CYP51A1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H