Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMI5OXG)

• Drug Name: Latanoprost Drug Info
• Synonyms: Catioprost; Xalatan; Latanoprost free acid; L1167_SIGMA; PhXA41; XA41; AR-202; Nova-21027; PHXA-41; XA-41; Xalatan (TN); Latanoprost (JAN/USAN/INN); PhXA34 [as 15(R,S)-isomer]; Isopropyl (5Z,9alpha,11alpha,15R)-9,11,15-trihydroxy-17-phenyl-18,19,20-trinorprost-5-en-1-oate; Isopropyl (5Z,9alpha,11alpha,15R)-9,11,15-trihydroxy-17-phenyl-18,19,20-trinor-prost-5-en-1-oate; Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((3R)-3-hydroxy-5-phenylpentyl)cyclopentyl)-5-heptenoate; Propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate; Propan-2-yl (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoate
• Therapeutic Class: Antihypertensive Agents
• Cross-matching ID:
  PubChem CID: 5311221
  ChEBI ID: CHEMBL1051
  CAS Number: CAS 130209-82-4
  TTD Drug ID: D0C6NM
  VARIDT Drug ID: DR00168
  ACDINA Drug ID: D01199

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Proteasome	2.36	0.00e+0	44/46 (95.65%)	PSMA6;PSMA3;PSMA4;...
Parkinson disease	2.04	0.00e+0	176/249 (70.68%)	PSMA6;PSMA3;PSMA4;...
Prion disease	1.96	3.12e-3	209/273 (76.56%)	CAV1;PSMA6;PSMA3;...
Mineral absorption	1.93	4.67e-3	48/60 (80%)	MT1M;MT1E;MT1F;...
Asthma	1.90	5.61e-3	25/31 (80.65%)	HLA-DRA;HLA-DQB1;HLA-DPB1;...
Systemic lupus erythematosus	1.89	4.67e-3	45/135 (33.33%)	HLA-DRA;HLA-DQB1;HLA-DPB1;...
Huntington disease	1.87	4.01e-3	233/306 (76.14%)	PSMA6;POLR2I;PSMA3;...
Intestinal immune network for IgA production	1.80	8.18e-3	38/48 (79.17%)	HLA-DRA;HLA-DQB1;HLA-DPB1;...
Hematopoietic cell lineage	1.78	1.04e-2	90/99 (90.91%)	HLA-DRA;ANPEP;HLA-DQB1;...
Rheumatoid arthritis	1.77	1.03e-2	78/93 (83.87%)	HLA-DRA;HLA-DQB1;HLA-DPB1;...
Oxidative phosphorylation	1.76	9.35e-3	93/133 (69.92%)	ATP5F1C;NDUFB3;PPA1;...
Malaria	1.72	2.34e-2	44/50 (88%)	HBB;SDC2;CD40;...
Spinocerebellar ataxia	1.70	2.95e-2	128/143 (89.51%)	PSMA6;PSMA3;PSMA4;...
Nitrogen metabolism	1.67	4.21e-2	16/17 (94.12%)	CA2;CA12;CA4;...
Arginine and proline metabolism	1.66	4.11e-2	39/50 (78%)	AOC1;GATM;ALDH2;...
Glycine, serine and threonine metabolism	1.64	4.67e-2	31/40 (77.5%)	DLD;GATM;PGAM1;...
Melanogenesis	-1.73	4.97e-2	74/101 (73.27%)	GNAQ;TCF7;ADCY2;...
Regulation of lipolysis in adipocytes	-1.85	1.35e-2	52/55 (94.55%)	ADCY1;FABP4;PLAAT3;...
Basal cell carcinoma	-1.92	0.00e+0	41/63 (65.08%)	FZD7;GLI3;BMP4;...
Cushing syndrome	-1.97	0.00e+0	125/155 (80.65%)	FZD7;MAPK3;AGT;...
Cortisol synthesis and secretion	-2.03	0.00e+0	58/65 (89.23%)	PLCB2;CYP21A2;STAR;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	3H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Liver

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	8uM	72H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼