Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMI6E0R)

Drug Name
Midostaurin Drug Info
Synonyms
PKC412; 120685-11-2; Cgp 41251; 4'-N-Benzoylstaurosporine; CGP-41251; Benzoylstaurosporine; PKC-412; RYDAPT; PKC 412; UNII-ID912S5VON; N-Benzoylstaurosporine; ID912S5VON; CHEMBL608533; CHEBI:63452; Cgp 41 251; N-[(5S,6R,7R,9R)-6-methoxy-5-methyl-14-oxo-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-7-yl]-N-methylbenzamide; PKC-412(Midostaurin); Midostaurin (PKC412); Midostaurin (USAN/INN); Midostaurin [USAN:INN]; CGP 41231; Rydapt (TN); CPG 41251
Therapeutic ClassAnticancer Agents
Cross-matching ID
PubChem CID
9829523
ChEBI ID
CHEMBL608533
CAS Number
CAS 120685-11-2
TTD Drug ID
D07NVU
VARIDT Drug ID
DR01370
INTEDE Drug ID
DR1090
ACDINA Drug ID
D00431

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
TNF signaling pathway 2.27 0.00e+0 103/112 (91.96%) CXCL10;MMP9;NFKBIA;...
NF-kappa B signaling pathway 2.20 0.00e+0 90/104 (86.54%) RELB;NFKBIA;BIRC3;...
Viral protein interaction with cytokine and cytokine re... 2.00 0.00e+0 84/100 (84%) CXCL10;CXCL9;CXCL2;...
Toll-like receptor signaling pathway 1.93 0.00e+0 94/104 (90.38%) SPP1;CXCL10;IKBKE;...
Small cell lung cancer 1.90 8.18e-3 90/92 (97.83%) NFKBIA;BIRC3;MYC;...
Cytokine-cytokine receptor interaction 1.85 1.70e-2 246/295 (83.39%) CXCL10;CXCL9;CXCL2;...
ECM-receptor interaction 1.84 1.75e-2 80/88 (90.91%) SPP1;ITGB5;COL4A5;...
NOD-like receptor signaling pathway 1.77 2.81e-2 145/181 (80.11%) IKBKE;NFKBIA;BIRC3;...
Transcriptional misregulation in cancer 1.77 2.50e-2 158/192 (82.29%) MMP9;NUPR1;BIRC3;...
IL-17 signaling pathway 1.74 2.76e-2 84/94 (89.36%) CXCL10;IKBKE;MMP9;...
Amoebiasis 1.73 2.51e-2 99/102 (97.06%) CXCL2;COL4A5;NFKB1;...
Chemokine signaling pathway 1.72 2.47e-2 163/192 (84.9%) CXCL10;CXCL9;NFKBIA;...
AGE-RAGE signaling pathway in diabetic complications 1.72 2.59e-2 97/100 (97%) COL4A5;NFKB1;PLCB1;...
Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 1.71 2.92e-2 20/26 (76.92%) PIGB;PIGT;PIGV;...
RNA transport -1.68 3.32e-2 128/186 (68.82%) SRRM1;EIF4A1;NXF1;...
Cholesterol metabolism -1.71 2.21e-2 44/50 (88%) ABCG5;VDAC1;LIPA;...
Spliceosome -1.72 2.33e-2 101/150 (67.33%) SART1;SF3A3;SNRPA1;...
Arginine and proline metabolism -1.76 2.05e-2 39/50 (78%) PRODH2;GOT2;CKM;...
Retinol metabolism -1.77 2.31e-2 41/68 (60.29%) ADH6;DGAT1;CYP2C8;...
Steroid biosynthesis -1.80 1.80e-2 19/20 (95%) FDFT1;LBR;SQLE;...
Prion disease -1.82 1.94e-2 209/273 (76.56%) CSNK2B;ATP5PB;PPP3R1;...
DNA replication -1.83 2.33e-2 34/36 (94.44%) MCM5;RFC1;MCM7;...
Cysteine and methionine metabolism -1.86 1.46e-2 43/50 (86%) LDHB;LDHA;ADI1;...
Parkinson disease -1.91 9.72e-3 176/249 (70.68%) PARK7;PSMB1;VDAC1;...
Glycine, serine and threonine metabolism -1.93 9.72e-3 31/40 (77.5%) SRR;DAO;AOC2;...
Proteasome -2.12 0.00e+0 44/46 (95.65%) PSMB1;PSMA5;PSMB3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
K-562 CVCL_0004 Homo sapiens 0.01uM - 10uM 4H, 24H
HAP1 CVCL_Y019 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 BRD4 (-) 1 CVCL_SF59 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 CDK4 (-) 1 CVCL_SI36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 HDAC5 (-) 1 CVCL_SR11 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 ITGA4 (-) 1 CVCL_ST27 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 MAPK8 (-) 1 CVCL_SW99 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PIK3CA (-) 1 CVCL_TD60 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKACA (-) 1 CVCL_TG70 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKCQ (-) CVCL_TG92 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 RELA (-) 1 CVCL_TI75 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 SRC (-) 1 CVCL_TQ36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 TP53 (-) 1 CVCL_RJ70 Homo sapiens 0.66uM - 3.33uM 24H
Multiple myeloma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
KMS-34 CVCL_1333 Homo sapiens 0.01uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Lymph node
Burkitt lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BJAB CVCL_5711 Homo sapiens 0.01uM - 10uM 4H
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HBL-1 CVCL_4213 Homo sapiens 0.01uM - 10uM 4H, 24H
OCI-Ly10 CVCL_8795 Homo sapiens 0.01uM - 10uM 24H
OCI-Ly19 CVCL_8797 Homo sapiens 0.01uM - 10uM 4H, 24H
OCI-Ly3 CVCL_8796 Homo sapiens 0.01uM - 10uM 4H, 24H
TMD8 CVCL_A440 Homo sapiens 0.01uM - 10uM 4H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute B-lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NALM-6 CVCL_0092 Homo sapiens 0.01uM - 10uM 24H
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 4H, 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
SK-MEL-5 CVCL_0527 Homo sapiens 0.01uM - 10uM 24H