Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMI6P91)

Drug Name
1-Methyl-1,2,3,4-tetrahydro-isoquinoline-6,7-diol Drug Info
Synonyms
1-methyl-1,2,3,4-tetrahydroisoquinoline-6,7-diol; 525-72-4; (+/-) Salsolinol; CHEMBL416732; 1-Methyl-6,7-dihydroxytetrahydroisoquinoline; CHEBI:88801; (R)-Salsolinol; IBRKLUSXDYATLG-UHFFFAOYSA-N; 1-Methyl-1,2,3,4-tetrahydro-isoquinoline-6,7-diol; 6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-1-methyl-; 1-Methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline; Sasolinol; (+)-Salsolinol; (R)-(+)-Salsolinol; (+)-(R)-Salsolinol; AC1L1H1L; Oprea1_470083; SCHEMBL1627427; CTK4J6115; 1,2,3,4-TETRAHYDRO-1-METHYL-6,7-ISOQUINOLINEDIOL
Cross-matching ID
PubChem CID
54456
ChEBI ID
CHEMBL416732
CAS Number
CAS 525-72-4
TTD Drug ID
D04JUJ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Th17 cell differentiation -1.62 4.16e-2 95/107 (88.79%) IL21;PPP3R1;RARA;...
NF-kappa B signaling pathway -1.63 4.33e-2 90/104 (86.54%) BIRC2;CD40LG;PTGS2;...
NOD-like receptor signaling pathway -1.63 4.10e-2 145/181 (80.11%) IKBKE;CASP5;TP53BP1;...
Measles -1.64 4.22e-2 133/139 (95.68%) TAB2;MAPK10;FAS;...
Pertussis -1.65 3.75e-2 64/76 (84.21%) MAPK8;NOD1;GNAI2;...
Other glycan degradation -1.65 3.87e-2 13/18 (72.22%) MANBA;HEXB;MAN2B1;...
Ovarian steroidogenesis -1.66 3.50e-2 41/51 (80.39%) ADCY2;CYP17A1;HSD3B2;...
Th1 and Th2 cell differentiation -1.68 3.17e-2 80/92 (86.96%) PPP3R1;IL2RG;IL12RB1;...
Fluid shear stress and atherosclerosis -1.68 3.07e-2 123/139 (88.49%) MAPK10;MAP2K5;NOX1;...
Hypertrophic cardiomyopathy -1.68 3.26e-2 81/90 (90%) ITGB5;ATP2A1;CACNB3;...
Tuberculosis -1.69 3.38e-2 159/180 (88.33%) IL10RB;IFNB1;RAB5A;...
Pathogenic Escherichia coli infection -1.71 2.62e-2 152/197 (77.16%) MYO1F;ABI1;SEC24C;...
Dilated cardiomyopathy -1.72 2.81e-2 86/96 (89.58%) ADCY6;ITGB5;ATP2A1;...
Apelin signaling pathway -1.73 2.55e-2 117/137 (85.4%) GNAI2;ADCY6;GNB2;...
Yersinia infection -1.74 2.56e-2 120/137 (87.59%) NFATC1;MAPK8;CD8B;...
Shigellosis -1.74 2.80e-2 180/246 (73.17%) ACTN1;PLCD1;GABARAPL1;...
Toxoplasmosis -1.75 2.95e-2 103/112 (91.96%) TLR2;TGFB2;HSPA1A;...
Inflammatory bowel disease -1.76 3.01e-2 58/65 (89.23%) NOD2;IL21;IL2RG;...
Mucin type O-glycan biosynthesis -1.77 2.46e-2 20/36 (55.56%) GALNT11;GCNT1;GALNT7;...
Leishmaniasis -1.82 1.76e-2 67/77 (87.01%) ITGB2;C3;PTGS2;...
Malaria -1.83 1.84e-2 44/50 (88%) ICAM1;TLR2;TGFB2;...
Phagosome -1.83 2.21e-2 118/152 (77.63%) ITGB5;SCARB1;ITGB2;...
PPAR signaling pathway -1.87 1.84e-2 66/74 (89.19%) NR1H3;HMGCS1;ME3;...
Hematopoietic cell lineage -1.91 1.23e-2 90/99 (90.91%) CD33;CD19;CR2;...
Biosynthesis of unsaturated fatty acids -2.09 0.00e+0 21/27 (77.78%) HSD17B4;HACD2;SCD5;...
Steroid biosynthesis -2.26 0.00e+0 19/20 (95%) TM7SF2;SOAT1;CYP51A1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H