Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMI796T)

Drug Name
BMS-A Drug Info
Synonyms CCR2 antagonists (inflammatory/metabolic diseases); CCR2 antagonists (inflammatory/metabolic diseases), Bristol-Myers Squibb
Cross-matching ID
PubChem CID
10474339
ChEBI ID
CHEMBL93672
CAS Number
CAS 202821-81-6
TTD Drug ID
D02XNT

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.48 0.00e+0 34/36 (94.44%) MCM4;MCM5;POLE2;...
Cell cycle 2.19 0.00e+0 110/124 (88.71%) CCND3;CDC20;CCNA2;...
Mismatch repair 2.09 0.00e+0 22/23 (95.65%) MSH6;RPA2;PCNA;...
Oocyte meiosis 2.06 0.00e+0 90/129 (69.77%) CDC20;PRKACA;CCNB2;...
Hypertrophic cardiomyopathy 2.06 0.00e+0 81/90 (90%) ITGA6;TPM4;TNNC1;...
Dilated cardiomyopathy 1.98 1.66e-3 86/96 (89.58%) ITGA6;TPM4;TNNC1;...
Progesterone-mediated oocyte maturation 1.93 1.42e-3 75/100 (75%) CCNA2;PRKACA;CCNB2;...
Focal adhesion 1.86 1.24e-3 180/201 (89.55%) MET;ITGA6;CAV2;...
Pyrimidine metabolism 1.83 6.63e-3 40/56 (71.43%) RRM2;RRM1;TYMS;...
Acute myeloid leukemia 1.79 1.19e-2 66/67 (98.51%) CCNA2;JUP;CCND1;...
Nucleotide excision repair 1.75 2.17e-2 40/47 (85.11%) RAD23B;POLE2;RPA2;...
Homologous recombination 1.74 2.24e-2 35/41 (85.37%) RAD54B;RPA2;RAD51;...
AGE-RAGE signaling pathway in diabetic complications 1.73 2.06e-2 97/100 (97%) TGFBR2;COL4A3;CCND1;...
Renal cell carcinoma 1.72 1.99e-2 68/69 (98.55%) MET;HRAS;TGFB1;...
Regulation of actin cytoskeleton 1.72 1.92e-2 185/218 (84.86%) ITGA6;ITGA4;MYH10;...
Arrhythmogenic right ventricular cardiomyopathy 1.70 2.17e-2 70/77 (90.91%) ITGA6;ITGA4;JUP;...
Fanconi anemia pathway 1.68 3.10e-2 36/54 (66.67%) USP1;RPA2;RAD51;...
Cardiac muscle contraction 1.68 2.93e-2 64/87 (73.56%) TPM4;TNNC1;ACTC1;...
Proteoglycans in cancer 1.66 3.56e-2 172/205 (83.9%) MET;CAV2;PRKACA;...
Adrenergic signaling in cardiomyocytes 1.64 4.08e-2 130/150 (86.67%) TPM4;TNNC1;PRKACA;...
ECM-receptor interaction 1.63 4.35e-2 80/88 (90.91%) ITGA6;COL4A3;ITGA4;...
Pentose phosphate pathway -1.62 4.27e-2 25/30 (83.33%) FBP1;RBKS;PGD;...
Tyrosine metabolism -1.64 3.98e-2 30/36 (83.33%) ADH1B;FAH;ADH6;...
Cholesterol metabolism -1.65 3.34e-2 44/50 (88%) LDLR;LRP2;APOA4;...
Glycine, serine and threonine metabolism -1.67 3.24e-2 31/40 (77.5%) AMT;PIPOX;SDS;...
Ovarian steroidogenesis -1.67 3.32e-2 41/51 (80.39%) CYP19A1;CYP11A1;LDLR;...
Linoleic acid metabolism -1.72 2.58e-2 21/29 (72.41%) CYP2C8;ALOX15;CYP2J2;...
Glycosaminoglycan degradation -1.72 2.75e-2 19/19 (100%) GLB1;IDS;NAGLU;...
Biosynthesis of unsaturated fatty acids -1.73 2.80e-2 21/27 (77.78%) HSD17B4;SCD5;ACAA1;...
Mitophagy -1.73 2.94e-2 56/68 (82.35%) OPTN;RPS27A;CSNK2A1;...
Phagosome -1.75 2.43e-2 118/152 (77.63%) SFTPA2;RAB5A;HLA-G;...
Arachidonic acid metabolism -1.82 1.46e-2 48/61 (78.69%) ALOX15B;CYP2C9;ALOX5;...
Collecting duct acid secretion -1.83 1.21e-2 22/27 (81.48%) ATP6V0A1;ATP6V1E1;ATP6V1G1;...
Lysosome -1.87 8.95e-3 115/128 (89.84%) AP3M2;IDUA;AGA;...
Ferroptosis -1.87 1.01e-2 36/41 (87.8%) PCBP2;NCOA4;GCLC;...
PPAR signaling pathway -1.89 7.19e-3 66/74 (89.19%) APOA1;FABP6;GK;...
Oxidative phosphorylation -1.92 6.71e-3 93/133 (69.92%) ATP4B;ATP5MC3;NDUFA8;...
Other glycan degradation -1.96 6.04e-3 13/18 (72.22%) AGA;ENGASE;MAN2C1;...
Steroid biosynthesis -1.96 5.03e-3 19/20 (95%) NSDHL;DHCR7;CYP51A1;...
alpha-Linolenic acid metabolism -2.03 0.00e+0 17/25 (68%) PLA2G4C;PLA2G2A;PLA2G12A;...
Metabolism of xenobiotics by cytochrome P450 -2.04 0.00e+0 49/77 (63.64%) GSTM4;GSTM3;CYP2D6;...
Mineral absorption -2.28 0.00e+0 48/60 (80%) ATOX1;MT2A;ATP1A2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 10uM 6H
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 10uM 6H
MDST8 CVCL_1400 Homo sapiens 10uM 6H
NCI-H508 CVCL_1561 Homo sapiens 10uM 6H
SNU-1040 CVCL_5001 Homo sapiens 10uM 6H
SNU-C4 CVCL_5008 Homo sapiens 10uM 6H
SNU-C5 CVCL_5009 Homo sapiens 10uM 6H
SW480 CVCL_0546 Homo sapiens 10uM 6H
SW620 CVCL_0547 Homo sapiens 10uM 6H
SW948 CVCL_0550 Homo sapiens 10uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 10uM 6H
HT115 CVCL_1294 Homo sapiens 10uM 6H
RKO CVCL_0504 Homo sapiens 10uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 10uM 6H
SNG-M CVCL_1707 Homo sapiens 10uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 10uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 10uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 10uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 10uM 6H
T3M-10 CVCL_1729 Homo sapiens 10uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 10uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 10uM 6H
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 10uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 10uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 10uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 10uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 10uM 6H
OV7 CVCL_1623 Homo sapiens 10uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 10uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 10uM 6H
RMUG-S CVCL_1666 Homo sapiens 10uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 10uM 6H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 10uM 6H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 10uM 6H
PL-21 CVCL_2161 Homo sapiens 10uM 6H
SKM-1 CVCL_0010 Homo sapiens 10uM 6H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 10uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 10uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 10uM 6H