Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMI79JN)

Drug Name
SKF-96365 Drug Info
Synonyms
SK-96365; 1-[2-(4-methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl]-1H-imidazole; 1-[2-(4-Methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl]imidazole; 1-[beta-[3-(4-Methoxyphenyl)propoxy]-4-methoxyphenethyl]-1H-imidazole; 1-(2-(3-(4-Methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole; AC1L2XSB; SKF-96365 free base; Imidazole-based ligand, 15; KBioSS_000197; KBioGR_000197; BSPBio_001477; SCHEMBL722014; GTPL2441; CHEMBL258502; KBio3_000394; KBio2_000197; KBio3_000393; KBio2_005333; KBio2_002765; CHEBI:91847; BDBM21164
Cross-matching ID
PubChem CID
104955
ChEBI ID
CHEMBL145121
CAS Number
CAS 130495-35-1
TTD Drug ID
D0HQ1W

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
ECM-receptor interaction 2.12 0.00e+0 80/88 (90.91%) ITGA6;VWF;LAMA4;...
Focal adhesion 2.07 5.54e-3 180/201 (89.55%) ITGA6;VWF;LAMA4;...
Amoebiasis 2.04 3.69e-3 99/102 (97.06%) CXCL3;CXCL8;LAMA4;...
Hypertrophic cardiomyopathy 1.96 5.54e-3 81/90 (90%) ITGA6;TPM2;DES;...
Dilated cardiomyopathy 1.90 1.77e-2 86/96 (89.58%) ITGA6;TPM2;DES;...
Ribosome biogenesis in eukaryotes 1.86 1.66e-2 52/108 (48.15%) GNL2;RBM28;DKC1;...
Glycine, serine and threonine metabolism -1.63 4.58e-2 31/40 (77.5%) CBS;SARDH;GLDC;...
Ascorbate and aldarate metabolism -1.66 3.70e-2 15/30 (50%) RGN;AKR1A1;ALDH3A2;...
Amino sugar and nucleotide sugar metabolism -1.66 3.93e-2 38/48 (79.17%) HK2;FPGT;CYB5R4;...
Histidine metabolism -1.68 3.19e-2 16/22 (72.73%) HAL;ALDH3A2;FTCD;...
Cysteine and methionine metabolism -1.68 3.23e-2 43/50 (86%) BCAT2;KYAT1;MDH1;...
Fanconi anemia pathway -1.69 3.00e-2 36/54 (66.67%) RAD51;RAD51C;MLH1;...
Drug metabolism -1.71 2.14e-2 78/151 (51.66%) MGST2;GSTM3;DPYS;...
Pentose and glucuronate interconversions -1.75 1.53e-2 17/34 (50%) AKR1A1;UGP2;UGT2B28;...
Oxidative phosphorylation -1.83 7.09e-3 93/133 (69.92%) ATP5MC3;NDUFB4;NDUFA2;...
Mismatch repair -1.83 5.90e-3 22/23 (95.65%) RFC3;RPA3;POLD3;...
Metabolism of xenobiotics by cytochrome P450 -1.89 4.43e-3 49/77 (63.64%) ADH6;UGT2A3;ALDH3B1;...
Steroid biosynthesis -1.90 3.80e-3 19/20 (95%) LIPA;HSD17B7;SQLE;...
Glutathione metabolism -1.97 2.95e-3 43/57 (75.44%) GGT1;MGST2;GPX7;...
Folate biosynthesis -2.00 1.77e-3 23/26 (88.46%) PTS;QDPR;GGH;...
Collecting duct acid secretion -2.00 2.21e-3 22/27 (81.48%) TCIRG1;ATP6V1C1;ATP6V0E1;...
Glycolysis / Gluconeogenesis -2.04 2.95e-3 56/67 (83.58%) LDHB;ADH1A;ADH1C;...
One carbon pool by folate -2.05 0.00e+0 15/20 (75%) FTCD;TYMS;MTHFD2;...
DNA replication -2.42 0.00e+0 34/36 (94.44%) MCM3;POLE2;MCM7;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 12.5uM 6H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.37uM - 10uM 6H, 24H
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 6H, 24H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H