Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMI7FVQ)

• Drug Name: Metyrapone Drug Info
• Synonyms: MYT; Mepyrapone; Metapirone; Metapyron; Methapyrapone; Methbipyranone; Methopirapone; Methopyrapone; Methopyrinine; Methopyrone; Metirapona; Metopiron; Metopirone; Metopyrone; Metroprione; Metyrapon; Metyraponum; Alliance Brand of Metyrapone; Metyrapone Alliance Brand; Metyrapone Novartis Brand; Novartis Brand of Metyrapone; Su 4885; METOPIRONE (TN); Metirapona [INN-Spanish]; Metopirone (TN); Metyraponum [INN-Latin]; Su-4885; Metyrapone (JP15/USP/INN); Metyrapone [USAN:INN:BAN:JAN]; 1,2-Di-3-pyridyl-2-methyl-1-propanone; 2-Methyl-1,2-bis(3-pyridyl)-1-propanone; 2-Methyl-1,2-di-3-pyridinyl-1-propanone; 2-Methyl-1,2-di-3-pyridyl-1-propanone; 2-methyl-1,2-dipyridin-3-yl-propan-1-one; 2-methyl-1,2-dipyridin-3-ylpropan-1-one
• Therapeutic Class: Antimetabolites
• Cross-matching ID:
  PubChem CID: 4174
  ChEBI ID: CHEMBL934
  CAS Number: CAS 54-36-4
  TTD Drug ID: D0Q9JT
  ACDINA Drug ID: D00426

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Pentose and glucuronate interconversions	-1.64	4.90e-2	17/34 (50%)	RPE;CRYL1;SORD;...
Epstein-Barr virus infection	-1.66	4.54e-2	189/202 (93.56%)	CD3D;PSMD12;HLA-E;...
Type I diabetes mellitus	-1.66	4.51e-2	38/43 (88.37%)	PTPRN2;TNF;IL1B;...
Metabolism of xenobiotics by cytochrome P450	-1.67	4.29e-2	49/77 (63.64%)	CYP1A1;HPGDS;MGST3;...
Toll-like receptor signaling pathway	-1.69	3.64e-2	94/104 (90.38%)	TLR6;TNF;TICAM1;...
Ascorbate and aldarate metabolism	-1.72	2.56e-2	15/30 (50%)	ALDH1B1;UGDH;ALDH3A2;...
Malaria	-1.73	2.18e-2	44/50 (88%)	IL1B;ITGB2;VCAM1;...
Porphyrin and chlorophyll metabolism	-1.73	2.32e-2	23/43 (53.49%)	UGT2B17;HCCS;UGT2B28;...
Leishmaniasis	-1.74	2.39e-2	67/77 (87.01%)	ITGAM;ELK1;FCGR3B;...
Phagosome	-1.77	1.83e-2	118/152 (77.63%)	TLR6;ATP6V0D1;FCGR2B;...
Autophagy	-1.77	1.97e-2	113/169 (66.86%)	IGBP1;ERN1;AMBRA1;...
Intestinal immune network for IgA production	-1.82	9.61e-3	38/48 (79.17%)	TNFSF13;HLA-DPA1;ITGB7;...
Asthma	-1.85	8.15e-3	25/31 (80.65%)	HLA-DPA1;FCER1G;CD40;...
Viral protein interaction with cytokine and cytokine re...	-1.87	7.68e-3	84/100 (84%)	IL24;IL6ST;IL18;...
Ether lipid metabolism	-1.88	7.12e-3	32/49 (65.31%)	GAL3ST1;PLD1;PLA2G2D;...
Antigen processing and presentation	-1.93	3.20e-3	60/78 (76.92%)	HLA-E;NFYB;IFI30;...
Protein processing in endoplasmic reticulum	-1.96	3.66e-3	127/171 (74.27%)	SEC23A;EIF2AK3;CUL1;...
Allograft rejection	-1.96	4.27e-3	32/38 (84.21%)	HLA-E;HLA-B;FAS;...
PPAR signaling pathway	-1.97	0.00e+0	66/74 (89.19%)	APOC3;FABP6;SCP2;...
Graft-versus-host disease	-2.01	0.00e+0	32/42 (76.19%)	KLRD1;TNF;IL1B;...
Ferroptosis	-2.03	0.00e+0	36/41 (87.8%)	SLC39A14;TFRC;FTL;...
Viral myocarditis	-2.07	0.00e+0	53/60 (88.33%)	HLA-E;ITGB2;HLA-B;...
Autoimmune thyroid disease	-2.11	0.00e+0	46/53 (86.79%)	HLA-B;FAS;HLA-DPA1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	8uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H, 24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H, 24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H, 24H	Show ▼