Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMI7J1L)

• Drug Name: A-740003 Drug Info
• Synonyms: A-740003; 861393-28-4; A 740003; n-(1-(((cyanoamino)(5-quinolinylimino)methyl)amino)-2,2-dimethylpropyl)-3,4-dimethoxybenzeneacetamide; (E)-N-(1-((cyanamido(quinolin-5-ylamino)methylene)amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide; CHEMBL255787; SCHEMBL3357263; MolPort-044-567-676; EX-A1789; AKOS022184697; RL05324; CS-0297; Benzeneacetamide, N-(1-(((cyanoamino)(5-quinolinylamino)methylene)amino)-2,2-dimethylpropyl)-3,4-dimethoxy-; HY-50697; Benzeneacetamide, N-(1-(((cyanoamino)(5-quinolinylimino)methyl)ami
• Cross-matching ID:
  PubChem CID: 23232014
  ChEBI ID: CHEMBL255787
  CAS Number: CAS 861393-28-4
  TTD Drug ID: D0U5ML

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Primary immunodeficiency	2.00	1.94e-2	33/38 (86.84%)	IGLL1;IL7R;CD3D;...
Collecting duct acid secretion	-1.84	4.63e-2	22/27 (81.48%)	ATP4B;ATP4A;ATP6V1A;...
Mineral absorption	-2.00	3.09e-2	48/60 (80%)	ATOX1;HMOX1;MT2A;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 10uM	24H	Hide ▲

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 10uM	24H	Hide ▲