Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMI94L1)

Drug Name
REV-5901 Drug Info
Synonyms
Rev 5901; REV-5901; 101910-24-1; RG 5901; PF 5901; alpha-Pentyl-3-(2-quinolinylmethoxy)benzenemethanol; 1-[3-(quinolin-2-ylmethoxy)phenyl]hexan-1-ol; CHEMBL8747; MLS000069771; REV-901; PF-5901; SMR000058509; alpha-Pentyl-3-[2-quinolinylmethoxy]benzyl alcohol; Benzenemethanol, alpha-pentyl-3-(2-quinolinylmethoxy)-; 1-(3-(quinolin-2-ylmethoxy)phenyl)hexan-1-ol; SR-01000076105; ACMC-20d0wb; Opera_ID_512; WNW5RYD8MG; UNII-WNW5RYD8MG; AC1L1JIU; Lopac0_001042; CBiol_001910; KBioGR_000242; BSPBio_001522; KBioSS_000242; MLS001076522
Cross-matching ID
PubChem CID
5059
ChEBI ID
CHEMBL8747
CAS Number
CAS 101910-24-1
TTD Drug ID
D0O8ZE

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.07 0.00e+0 34/36 (94.44%) POLE2;MCM5;PRIM1;...
Fanconi anemia pathway 2.04 5.55e-3 36/54 (66.67%) FANCI;HES1;CENPX;...
Cell cycle 1.93 1.11e-2 110/124 (88.71%) CDC20;SMC1A;MCM5;...
Arginine biosynthesis 1.88 1.39e-2 17/22 (77.27%) ASS1;GLS;ARG2;...
Pyrimidine metabolism 1.76 3.00e-2 40/56 (71.43%) NT5E;TYMS;CANT1;...
Complement and coagulation cascades 1.75 2.59e-2 76/85 (89.41%) CFI;C4BPA;SERPING1;...
Base excision repair 1.74 2.62e-2 29/33 (87.88%) POLE2;NEIL1;HMGB1;...
Synthesis and degradation of ketone bodies 1.68 3.88e-2 9/10 (90%) OXCT1;BDH1;BDH2;...
Mismatch repair 1.67 3.88e-2 22/23 (95.65%) RPA3;MSH6;RFC3;...
Homologous recombination 1.64 4.83e-2 35/41 (85.37%) RBBP8;TOPBP1;RPA3;...
Endocrine and other factor-regulated calcium reabsorpti... -1.68 4.80e-2 49/53 (92.45%) ESR1;FXYD2;DNM3;...
Melanogenesis -1.69 4.95e-2 74/101 (73.27%) MAPK1;CREB3L1;MAP2K2;...
Pancreatic secretion -1.71 4.34e-2 87/102 (85.29%) CPA3;RAP1A;KCNMA1;...
GnRH secretion -1.71 4.58e-2 60/64 (93.75%) TRPC1;AKT3;PLCB4;...
Tuberculosis -1.73 4.59e-2 159/180 (88.33%) APAF1;MAPK1;JAK1;...
Shigellosis -1.76 3.86e-2 180/246 (73.17%) ACTN4;FBXW11;ARPC1A;...
Phagosome -1.79 2.80e-2 118/152 (77.63%) RAB5B;MPO;MARCO;...
Neutrophil extracellular trap formation -1.80 3.16e-2 101/189 (53.44%) HDAC5;HDAC3;ELANE;...
Tryptophan metabolism -1.83 1.70e-2 35/42 (83.33%) DHTKD1;HADHA;AOC1;...
Salmonella infection -1.85 1.73e-2 198/249 (79.52%) DYNLT3;TLR2;RAB9A;...
Mitophagy -1.96 5.94e-3 56/68 (82.35%) CSNK2A2;ATG9A;GABARAPL2;...
Vibrio cholerae infection -1.99 7.42e-3 44/50 (88%) KCNQ1;ADCY3;SLC12A2;...
Salivary secretion -2.04 0.00e+0 76/93 (81.72%) KCNMA1;SLC12A2;STATH;...
Lysosome -2.13 0.00e+0 115/128 (89.84%) CD63;GLB1;CTSA;...
Collecting duct acid secretion -2.15 0.00e+0 22/27 (81.48%) ATP6V0D1;ATP6V0E1;ATP6V1B1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.001uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.001uM - 1.11uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.001uM - 1.11uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.001uM - 1.11uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.001uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.001uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.001uM - 1.11uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.001uM - 10uM 6H, 24H, 48H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.001uM - 1.11uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.001uM - 1.11uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.001uM - 1.11uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.001uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.001uM - 10uM 6H, 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.001uM - 0.22uM 24H