Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMIBLGH)

Drug Name
Cyanopindolol Drug Info
Synonyms
Cyanopindolol; 69906-85-0; CYANOPINDOLOL HEMIFUMARATE; 4-[3-(tert-butylamino)-2-hydroxypropoxy]-1H-indole-2-carbonitrile; (+-)-Cyanopindolol; (-)-Cyanopindolol; AC1L4E3D; CYANOPINDOLOL(+/-); GTPL132; SCHEMBL353756; CHEMBL378501; CTK8E9328; BDBM81499; CHEBI:125406; PDSP1_001601; PDSP2_001585; PDSP1_001094; PDSP2_001078; NSC707473; CAS_155346; NSC_155346; NSC-707473; 1H-Indole-2-carbonitrile, 4-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)-; NCI60_038172; RT-012114; SR-01000597973; L000210; SR-01000597973-1; BRD-A47884604-001-01-7
Cross-matching ID
PubChem CID
155346
ChEBI ID
CHEMBL378501
CAS Number
CAS 69906-85-0
TTD Drug ID
D0X8ZA

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Glutamatergic synapse -1.67 3.94e-2 97/114 (85.09%) ITPR2;PPP3CA;KCNJ3;...
Ferroptosis -1.68 3.97e-2 36/41 (87.8%) ACSL5;VDAC3;SLC11A2;...
Allograft rejection -1.68 4.08e-2 32/38 (84.21%) IL10;TNF;IL5;...
Protein digestion and absorption -1.72 2.67e-2 78/103 (75.73%) ATP1B1;SLC1A5;ATP1A2;...
Cytokine-cytokine receptor interaction -1.73 2.70e-2 246/295 (83.39%) IL36RN;IL25;CCR8;...
Morphine addiction -1.73 2.82e-2 80/91 (87.91%) PDE8A;PDE4C;GRK4;...
GABAergic synapse -1.74 2.76e-2 76/89 (85.39%) CACNA1F;SLC6A12;GNG7;...
Ether lipid metabolism -1.75 2.60e-2 32/49 (65.31%) PLA2G5;PLA2G6;LPCAT1;...
Oxidative phosphorylation -1.75 2.86e-2 93/133 (69.92%) NDUFB4;COX4I1;NDUFS1;...
Malaria -1.77 2.54e-2 44/50 (88%) SELP;THBS4;CD40;...
Hematopoietic cell lineage -1.83 1.57e-2 90/99 (90.91%) CD1C;GP1BA;TNF;...
Glycolysis / Gluconeogenesis -1.84 1.31e-2 56/67 (83.58%) HK1;PDHA2;DLAT;...
Phagosome -1.86 9.53e-3 118/152 (77.63%) ATP6V0A4;ITGB1;CANX;...
Proximal tubule bicarbonate reclamation -1.91 4.58e-3 21/23 (91.3%) GLUD1;CA4;ATP1B1;...
Asthma -1.93 5.72e-3 25/31 (80.65%) IL10;TNF;IL5;...
Viral protein interaction with cytokine and cytokine re... -1.94 3.81e-3 84/100 (84%) CCL19;PF4V1;TNFRSF1B;...
Intestinal immune network for IgA production -2.00 0.00e+0 38/48 (79.17%) IL10;CXCL12;MADCAM1;...
Steroid biosynthesis -2.06 0.00e+0 19/20 (95%) NSDHL;TM7SF2;CYP51A1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H