Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMIBNG2)

• Drug Name: Picrotoxin Drug Info
• Synonyms: Cocculin; Cocculus; Picrotox; Picrotoxine; Picrotoxinum; Sesquiterpene; Coques du levant; Coques du levant [French];Fish berry; Indian berry; Oriental berry; P 1675; Picrotin-Picrotoxinin; Picrotoxin (Compound of one mole Picrotoxinin and one mole Picrotin); Picrotoxinin-picrotin; Picrotin, compound with picrotoxinin (1:1); Picrotin, compd. with picrotoxinin (1:1); Picrotoxinin, compd. with picrotin (1:1); 3,6-Methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-, (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8bbeta,9S*))-, compd. with (1aR-(1aalpha,2abeta,3beta,6beta,6; 3,6-Methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-, (1aR,2aR,3S,6R,6aS,8aS,8bR,9S)-& (1aR,2aR,3S,6R,6aS,8aS,8bR,9R; 3,6-Methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-, [1aR-(1a.alpha.,2
• Therapeutic Class: Central Nervous System Stimulants
• Cross-matching ID:
  PubChem CID: 31304
  CAS Number: CAS 124-87-8
  TTD Drug ID: D0KR9U
  VARIDT Drug ID: DR00640

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
DNA replication	2.38	0.00e+0	34/36 (94.44%)	POLE2;MCM2;RFC2;...
Cell cycle	2.00	0.00e+0	110/124 (88.71%)	CDC45;E2F2;MCM2;...
Mismatch repair	1.83	2.24e-2	22/23 (95.65%)	RFC2;RFC3;MSH6;...
Parkinson disease	1.83	1.68e-2	176/249 (70.68%)	GNAS;CYC1;GPR37;...
Homologous recombination	1.80	1.68e-2	35/41 (85.37%)	RAD51;SSBP1;SEM1;...
Huntington disease	1.76	3.08e-2	233/306 (76.14%)	GRIA2;CYC1;TGM2;...
Oxidative phosphorylation	1.73	4.55e-2	93/133 (69.92%)	CYC1;NDUFS6;NDUFA8;...
Fanconi anemia pathway	1.71	4.61e-2	36/54 (66.67%)	FANCA;RAD51;RMI1;...
Steroid biosynthesis	1.70	4.75e-2	19/20 (95%)	DHCR7;CYP51A1;SQLE;...
Mucin type O-glycan biosynthesis	-1.67	3.71e-2	20/36 (55.56%)	GCNT3;GALNT7;B3GNT3;...
Lipid and atherosclerosis	-1.70	2.64e-2	190/215 (88.37%)	MAPK13;ICAM1;HSPD1;...
Pentose phosphate pathway	-1.71	2.59e-2	25/30 (83.33%)	ALDOA;PRPS1;H6PD;...
Autophagy	-1.73	2.23e-2	113/169 (66.86%)	RAF1;SNAP29;DAPK2;...
Inositol phosphate metabolism	-1.73	2.16e-2	66/73 (90.41%)	ITPKB;PIP5K1B;INPP4A;...
Graft-versus-host disease	-1.74	2.08e-2	32/42 (76.19%)	FASLG;IFNG;HLA-DQA1;...
Fructose and mannose metabolism	-1.75	2.14e-2	30/33 (90.91%)	GMPPA;PFKFB3;ALDOA;...
Asthma	-1.77	1.80e-2	25/31 (80.65%)	CD40;HLA-DQA1;HLA-DRA;...
Primary immunodeficiency	-1.81	1.15e-2	33/38 (86.84%)	LCK;TNFRSF13B;CIITA;...
Hematopoietic cell lineage	-1.85	4.78e-3	90/99 (90.91%)	IL1A;CD37;CD8B;...
Starch and sucrose metabolism	-1.86	3.13e-3	25/36 (69.44%)	UGP2;GBA3;MGAM;...
Rheumatoid arthritis	-1.86	3.44e-3	78/93 (83.87%)	CCL20;ITGAL;ATP6V1D;...
Legionellosis	-1.88	3.82e-3	51/57 (89.47%)	NFKB2;HSPD1;TNF;...
Glycolysis / Gluconeogenesis	-1.89	4.30e-3	56/67 (83.58%)	ALDH7A1;PGK1;ALDH3B1;...
Longevity regulating pathway	-1.89	4.91e-3	90/151 (59.6%)	RPS6KB1;PRKAA1;PRKACA;...
Galactose metabolism	-1.91	5.73e-3	26/31 (83.87%)	GAA;GLB1;LALBA;...
Intestinal immune network for IgA production	-1.91	6.88e-3	38/48 (79.17%)	CD40;TNFRSF17;AICDA;...
IL-17 signaling pathway	-1.94	8.60e-3	84/94 (89.36%)	MUC5AC;HSP90B1;CCL20;...
Antigen processing and presentation	-1.94	1.15e-2	60/78 (76.92%)	HLA-DOA;CIITA;KLRC3;...
Amino sugar and nucleotide sugar metabolism	-2.04	1.15e-2	38/48 (79.17%)	UGP2;GALT;HK2;...
Protein processing in endoplasmic reticulum	-2.08	2.29e-2	127/171 (74.27%)	EIF2AK1;SIL1;MAN1A1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H	Hide ▲

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H, 24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H	Show ▼