General Information of Drug (ID: DMID3F7)

Drug Name
NNC55-0396 Drug Info
Synonyms NNC 55-0396
Cross-matching ID
PubChem CID
9957280
ChEBI ID
CHEMBL1551597
CAS Number
CAS 357400-14-7
TTD Drug ID
D03BSR

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.51 0.00e+0 19/20 (95%) MSMO1;DHCR7;CYP51A1;...
Complement and coagulation cascades 2.14 0.00e+0 76/85 (89.41%) CD55;VWF;C1S;...
Ferroptosis 2.13 0.00e+0 36/41 (87.8%) SLC7A11;HMOX1;SLC3A2;...
Protein processing in endoplasmic reticulum 2.11 0.00e+0 127/171 (74.27%) HERPUD1;DDIT3;ATF4;...
Lysosome 2.06 0.00e+0 115/128 (89.84%) NPC1;PSAP;TPP1;...
PPAR signaling pathway 2.03 0.00e+0 66/74 (89.19%) SCD;HMGCS1;PCK2;...
Cholesterol metabolism 1.98 0.00e+0 44/50 (88%) LDLR;NPC1;CYP27A1;...
Terpenoid backbone biosynthesis 1.93 4.38e-3 18/22 (81.82%) HMGCS1;HMGCR;FDPS;...
Other glycan degradation 1.86 6.48e-3 13/18 (72.22%) NEU1;AGA;HEXA;...
Metabolism of xenobiotics by cytochrome P450 1.86 5.84e-3 49/77 (63.64%) CYP1B1;AKR1C1;GSTA1;...
Glycerolipid metabolism 1.84 8.49e-3 44/61 (72.13%) ALDH2;PLPP3;AKR1A1;...
Mineral absorption 1.81 1.26e-2 48/60 (80%) HMOX1;ATP2B1;CYBRD1;...
Phagosome 1.80 1.26e-2 118/152 (77.63%) HLA-B;SFTPA2;TUBA1A;...
Fluid shear stress and atherosclerosis 1.79 1.42e-2 123/139 (88.49%) HMOX1;VEGFA;ARHGEF2;...
Biosynthesis of unsaturated fatty acids 1.77 1.40e-2 21/27 (77.78%) SCD;FADS2;ELOVL5;...
Sphingolipid metabolism 1.77 1.60e-2 32/49 (65.31%) PLPP3;PSAP;NEU1;...
Steroid hormone biosynthesis 1.72 2.68e-2 43/61 (70.49%) CYP1B1;AKR1C2;AKR1C1;...
Coronavirus disease 1.71 2.53e-2 215/232 (92.67%) RPS4Y1;IRF9;MMP1;...
Various types of N-glycan biosynthesis 1.71 2.76e-2 26/39 (66.67%) MAN2A1;HEXA;HEXB;...
Glycosaminoglycan degradation 1.70 2.74e-2 19/19 (100%) HEXA;GUSB;HEXB;...
Amino sugar and nucleotide sugar metabolism 1.69 2.72e-2 38/48 (79.17%) GFPT1;GNPDA1;UGDH;...
Insulin resistance 1.67 3.93e-2 96/108 (88.89%) PCK2;TRIB3;IRS2;...
RNA polymerase -1.68 1.69e-2 23/31 (74.19%) POLR3F;POLR1C;POLR2E;...
Oxidative phosphorylation -1.69 1.61e-2 93/133 (69.92%) COX11;SDHC;ATP6V1B2;...
Base excision repair -1.76 5.52e-3 29/33 (87.88%) PARP2;APEX2;SMUG1;...
mRNA surveillance pathway -1.76 5.87e-3 71/98 (72.45%) NXF1;PPP2R5C;RNGTT;...
RNA degradation -1.78 4.69e-3 53/79 (67.09%) C1D;DCPS;LSM4;...
p53 signaling pathway -1.79 5.03e-3 63/73 (86.3%) CCND2;BID;CCNG1;...
Huntington disease -1.81 3.01e-3 233/306 (76.14%) PSMB2;CASP3;PIK3R4;...
Ribosome biogenesis in eukaryotes -1.82 2.61e-3 52/108 (48.15%) IMP4;TCOF1;NHP2;...
Mismatch repair -1.91 7.11e-4 22/23 (95.65%) POLD3;RPA1;POLD1;...
Pyrimidine metabolism -1.93 0.00e+0 40/56 (71.43%) CTPS2;RRM1;DTYMK;...
RNA transport -1.98 0.00e+0 128/186 (68.82%) FUS;EIF4A1;RAN;...
Oocyte meiosis -1.99 0.00e+0 90/129 (69.77%) PPP2R1A;PPP1CA;ADCY6;...
Homologous recombination -2.02 0.00e+0 35/41 (85.37%) BABAM1;NBN;RAD50;...
Proteasome -2.04 0.00e+0 44/46 (95.65%) SEM1;PSMB9;PSME1;...
Fanconi anemia pathway -2.05 0.00e+0 36/54 (66.67%) FAAP100;RPA2;TOP3A;...
Spliceosome -2.17 0.00e+0 101/150 (67.33%) PRPF18;SF3A2;DHX15;...
Progesterone-mediated oocyte maturation -2.25 0.00e+0 75/100 (75%) PIK3R1;KRAS;MAPK10;...
DNA replication -2.38 0.00e+0 34/36 (94.44%) RFC2;RPA3;POLE;...
Cell cycle -2.59 0.00e+0 110/124 (88.71%) CDK6;CDKN2D;CDC23;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 0.125uM - 30uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H