Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMIESYM)

• Drug Name: Desmethylclomipramine Drug Info
• Synonyms: Desmethylclomipramine; Norclomipramine; UNII-01DN47PPQG; 01DN47PPQG; N-Demethylclomipramine; Demethylchlorimipramine; Desmethylchlorimipramine; AC1LDNXR; SCHEMBL11384662; VPIXQGUBUKFLRF-UHFFFAOYSA-N; CHEBI:124969; ZINC2570877; API0007900; BRD-K52696183-003-01-0; 5H-Dibenz(b,f)azepine-5-propanamine, 3-chloro-10,11-dihydro-N-methyl-; 3-Chloro-10,11-dihydro-N-methyl-5H-dibenz(b,f)azepine-5-propanamine; 3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N-methylpropan-1-amine
• Cross-matching ID:
  PubChem CID: 622606
  ChEBI ID: CHEMBL124969
  CAS Number: CAS 303-48-0
  TTD Drug ID: D0L4CI

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Steroid biosynthesis	2.06	0.00e+0	19/20 (95%)	DHCR24;SQLE;FDFT1;...
Proximal tubule bicarbonate reclamation	2.00	5.10e-3	21/23 (91.3%)	CA2;ATP1B3;PCK2;...
PPAR signaling pathway	1.93	6.81e-3	66/74 (89.19%)	PLIN2;CD36;SCD5;...
Pancreatic secretion	1.84	2.30e-2	87/102 (85.29%)	CA2;CPA3;CLCA4;...
Protein digestion and absorption	1.79	3.47e-2	78/103 (75.73%)	SLC38A2;CPA3;COL15A1;...
Mineral absorption	1.76	3.57e-2	48/60 (80%)	ATP1B3;SLC26A3;MT1M;...
Carbohydrate digestion and absorption	1.74	4.08e-2	37/47 (78.72%)	HK2;SI;AKT3;...
Renin secretion	1.73	3.83e-2	61/69 (88.41%)	CALML3;CLCA4;CALML5;...
Oxidative phosphorylation	1.73	3.63e-2	93/133 (69.92%)	NDUFA4L2;ATP5PD;COX7A1;...
DNA replication	-1.89	1.31e-2	34/36 (94.44%)	SSBP1;RFC3;DNA2;...
Complement and coagulation cascades	-2.13	0.00e+0	76/85 (89.41%)	C4BPB;MBL2;C8G;...
Systemic lupus erythematosus	-2.13	0.00e+0	45/135 (33.33%)	CTSG;C8G;SNRPD1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Fibroblast

Nasopharyngeal carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
FIBRNPC	CVCL_UK07	Homo sapiens	10uM	6H, 24H	Hide ▲