Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMIFOXE)

• Drug Name: 1,4-Dithiothreitol Drug Info
• Synonyms: Cleland's reagent; Dithiothreitol; 1,4-Dithiothreitol; Dithiotreitol; 1,4-Dimercaptobutane-2,3-diol; dl-Dithiothreitol; rac-Dithiothreitol; Cleland reagent; 7634-42-6; 1,4-disulfanylbutane-2,3-diol; Clelands reagent; Sputolysin; DL-threo-1,4-Dimercapto-2,3-butanediol; 1,4-dimercapto-2,3-butanediol; 3483-12-3; 2,3-Butanediol, 1,4-dimercapto-; Threitol, 1,4-dithio-; 1,4-bis(sulfanyl)butane-2,3-diol; trans-1,4-Dimercaptobutane-2,3-diol; L-1,4-Dithiothreitol; L-Dithiothreitol; CHEBI:18320; 1,4-Bissulfanylbutane-2,3-diol
• Cross-matching ID:
  PubChem CID: 19001
  ChEBI ID: CHEMBL18320
  CAS Number: CAS 7634-42-6
  TTD Drug ID: D01GMJ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Primary bile acid biosynthesis	1.85	4.13e-2	15/17 (88.24%)	CYP7A1;CYP27A1;CYP39A1;...
Steroid biosynthesis	-2.15	0.00e+0	19/20 (95%)	HSD17B7;EBP;LIPA;...
Nicotinate and nicotinamide metabolism	-2.22	0.00e+0	25/35 (71.43%)	SIRT1;QPRT;NMRK2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Fibroblast

Nasopharyngeal carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
FIBRNPC	CVCL_UK07	Homo sapiens	10uM	6H, 24H	Hide ▲