Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMIFSO3)

• Drug Name: AZD-2461 Drug Info
• Synonyms: AZD2461; 1174043-16-3; AZD-2461; UNII-3K288XF5XJ; 3K288XF5XJ; AZD 2461; 4-(4-fluoro-3-(4-methoxypiperidine-1-carbonyl)benzyl)phthalazin-1(2H)-one; 4-[4-Fluoro-3-[(4-methoxypiperidin-1-yl)carbonyl]benzyl]phthalazin-1(2H)-one; 1(2H)-Phthalazinone, 4-[[4-fluoro-3-[(4-methoxy-1-piperidinyl)carbonyl]phenyl]methyl]-; 4-(4-Fluoro-3-((4-methoxypiperidin-1-yl)carbonyl)benzyl)phthalazin-1(2H)-one; 1(2H)-Phthalazinone, 4-((4-fluoro-3-((4-methoxy-1-piperidinyl)carbonyl)phenyl)methyl)-; HYNBNUYQTQIHJK-UHFFFAOYSA-N; SCHEMBL77012
• Cross-matching ID:
  PubChem CID: 44199317
  ChEBI ID: CHEMBL4098253
  CAS Number: CAS 1174043-16-3
  TTD Drug ID: D07OIO

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
DNA replication	2.22	0.00e+0	34/36 (94.44%)	PRIM1;POLE2;MCM6;...
Mismatch repair	1.93	1.26e-2	22/23 (95.65%)	PCNA;RFC2;SSBP1;...
Spliceosome	1.92	8.38e-3	101/150 (67.33%)	SRSF7;SRSF1;SNRPB2;...
One carbon pool by folate	1.75	4.70e-2	15/20 (75%)	TYMS;ALDH1L1;AMT;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Fibrocystic breast disease

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A (Parent)	CVCL_0598	Homo sapiens	1.11uM - 10uM	3H, 6H, 12H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 10uM	24H	Hide ▲

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 10uM	24H	Show ▼