Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMIG6FY)

• Drug Name: Amdinocillin Drug Info
• Synonyms: Coactin; Hexacillin; Mecilinamo; Mecillinam; Mecillinamum; Selexidin; Amdinocillin Mecillinam; Amdinocillin [USAN]; Penicillin HX; FL 1060; Ro 109070; Amdinocillin (USAN); Coactin (TN); FL-1060; Mecilinamo [INN-Spanish]; Mecillinam (INN); Mecillinamum [INN-Latin]; Ro 10-9070; Ro-10-9070; Rel-(2R,6S)-6-{[(1E)-azepan-1-ylmethylene]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; (2S,5R,6R)-6-(((Hexahydro-1H-azepin-1-yl)methylene)amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid; (2S,5R,6R)-6-(azepan-1-ylmethylideneamino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; (2S,5R,6R)-6-[(azepan-1-ylmethylidene)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; (2S,5R,6R)-6-{[(1E)-azepan-1-ylmethylidene]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; 6-((Hexahydro-1H-azepin-1-yl)methyleneamino)penicillanic acid; 6beta-[(azepan-1-ylmethylidene)amino]-2,2-dimethylpenam-3alpha-carboxylic acid
• Therapeutic Class: Antibiotics
• Cross-matching ID:
  PubChem CID: 36273
  CAS Number: CAS 32887-01-7
  TTD Drug ID: D0M1VC

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Mineral absorption	2.28	0.00e+0	48/60 (80%)	MT1X;MT1H;MT1F;...
Propanoate metabolism	1.97	5.33e-3	30/34 (88.24%)	LDHB;ACAT1;SUCLG2;...
Other types of O-glycan biosynthesis	-1.73	3.96e-2	29/47 (61.7%)	B4GALT2;POFUT2;GALNT12;...
Mitophagy	-1.77	3.29e-2	56/68 (82.35%)	TFE3;MRAS;ATF4;...
Autoimmune thyroid disease	-1.82	1.74e-2	46/53 (86.79%)	IL2;HLA-E;HLA-DRB1;...
Type I diabetes mellitus	-1.83	1.88e-2	38/43 (88.37%)	IL2;HLA-E;HLA-DRB1;...
Mucin type O-glycan biosynthesis	-1.88	1.31e-2	20/36 (55.56%)	B4GALT5;B3GNT3;GALNT12;...
Viral myocarditis	-1.90	1.17e-2	53/60 (88.33%)	HLA-DMB;RAC2;SGCD;...
Cardiac muscle contraction	-1.94	9.39e-3	64/87 (73.56%)	CACNA1S;MYL4;CACNG1;...
Allograft rejection	-2.05	0.00e+0	32/38 (84.21%)	IL2;HLA-E;HLA-DRB1;...
Graft-versus-host disease	-2.15	0.00e+0	32/42 (76.19%)	IL2;HLA-E;HLA-DRB1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H	Hide ▲

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H	Show ▼