Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMIGKA1)

Drug Name
Ozagrel Drug Info
Synonyms Ozagrel (ophthalmic, eye disorders); Ozagrel (ophthalmic, eye disorders), Kissei/ Teika
Cross-matching ID
PubChem CID
5282440
ChEBI ID
CHEMBL11662
CAS Number
CAS 82571-53-7
TTD Drug ID
D0C7AA

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.57 0.00e+0 34/36 (94.44%) MCM5;MCM2;POLD2;...
Fructose and mannose metabolism 2.10 1.52e-2 30/33 (90.91%) PFKP;HK2;SORD;...
Glycolysis / Gluconeogenesis 2.03 2.02e-2 56/67 (83.58%) PFKP;PGAM1;GPI;...
Pentose phosphate pathway 1.99 1.52e-2 25/30 (83.33%) PFKP;GPI;PFKL;...
Mismatch repair 1.96 1.21e-2 22/23 (95.65%) POLD2;PCNA;MSH6;...
Starch and sucrose metabolism 1.96 1.01e-2 25/36 (69.44%) GPI;GYG1;HK2;...
Citrate cycle (TCA cycle) 1.87 1.52e-2 30/30 (100%) ACO1;CS;IDH2;...
Base excision repair 1.85 1.90e-2 29/33 (87.88%) POLD2;FEN1;PCNA;...
Type II diabetes mellitus 1.83 2.02e-2 42/46 (91.3%) HK2;PIK3CB;PKM;...
Central carbon metabolism in cancer 1.79 2.73e-2 67/70 (95.71%) PFKP;PGAM1;HK2;...
Antigen processing and presentation 1.76 3.31e-2 60/78 (76.92%) HSPA4;CD74;HLA-DMB;...
Fc gamma R-mediated phagocytosis 1.72 4.05e-2 79/97 (81.44%) MARCKSL1;CRKL;PLPP3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 8uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 15uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 2.22uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H