Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMIHRNA)

Drug Name
Tolazamide Drug Info
Synonyms
Diabewas; Norglycin; Tolamide; Tolanase; Tolazamida; Tolazamidum; Tolazolamide; Tolinase; Pharmacia Brand of Tolazamide; T 2408; U 17835; Tolazamida [INN-Spanish]; Tolazamidum [INN-Latin]; Tolinase (TN); U-17835; Tolazamide (JP15/USP/INN); Tolazamide [USAN:INN:BAN:JAN]; N-(p-Toluenesulfonyl)-N'-hexamethyleniminourea; N-[(azepan-1-ylamino)carbonyl]-4-methylbenzenesulfonamide; N-(((hexahydro-1H-azepin-1-yl)amino)carbonyl)-4-methylbenzenesulfonamide; Benzenesulfonamide, {N-[[(hexahydro-1H-azepin-1-yl)amino]carbonyl]-4-methyl-}; N-(((Hexahydro-1H-azepin-1-yl)-amino)carbonyl)-4-methylbenzenesulfonamide; 1-(((((4-Methylphenyl)sulfonyl)amino)carbonyl)amino)azepane; 1-(Hexahydro-1-azepinyl)-3-p-tolylsulfonylurea; 1-(Hexahydro-1H-azepin-1-yl)-3-(p-toluenesulfonyl)urea; 1-(Hexahydro-1H-azepin-1-yl)-3-(p-tolylsulfonyl)urea; 1-(azepan-1-yl)-3-(4-methylphenyl)sulfonylurea; 3-azepan-1-yl-1-(4-methylphenyl)sulfonyl-urea; 4-(p-Tolylsulfonyl)-1,1-hexamethylene; 4-(p-Tolylsulfonyl)-1,1-hexamethylenesemicarbazide; 59866P
Therapeutic ClassHypoglycemic Agents
Cross-matching ID
PubChem CID
5503
ChEBI ID
CHEMBL817
CAS Number
CAS 1156-19-0
TTD Drug ID
D09FJB
INTEDE Drug ID
DR1611
ACDINA Drug ID
D00684

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Spliceosome 2.21 0.00e+0 101/150 (67.33%) PRPF4;HNRNPM;LSM5;...
Base excision repair 1.98 0.00e+0 29/33 (87.88%) FEN1;PCNA;NTHL1;...
DNA replication 1.93 2.06e-3 34/36 (94.44%) FEN1;PCNA;MCM3;...
Cell cycle 1.91 6.18e-3 110/124 (88.71%) CDC20;PLK1;SMC1A;...
Homologous recombination 1.90 4.94e-3 35/41 (85.37%) BRCA1;BABAM1;RBBP8;...
Ribosome biogenesis in eukaryotes 1.87 6.18e-3 52/108 (48.15%) IMP3;NXT1;NVL;...
Pyrimidine metabolism 1.85 6.18e-3 40/56 (71.43%) RRM2;CTPS1;ENTPD1;...
RNA polymerase 1.82 9.27e-3 23/31 (74.19%) POLR3K;POLR3E;POLR1E;...
Fanconi anemia pathway 1.70 2.20e-2 36/54 (66.67%) CENPX;BRCA1;POLI;...
Aminoacyl-tRNA biosynthesis 1.69 2.53e-2 15/66 (22.73%) CARS2;NARS2;QRSL1;...
Ferroptosis -1.70 2.09e-2 36/41 (87.8%) GPX4;GCLM;TF;...
AGE-RAGE signaling pathway in diabetic complications -1.71 2.07e-2 97/100 (97%) PLCG1;VEGFC;MAPK3;...
NF-kappa B signaling pathway -1.71 2.10e-2 90/104 (86.54%) CSNK2B;IL1R1;GADD45A;...
Tyrosine metabolism -1.72 2.03e-2 30/36 (83.33%) AOX1;MAOA;ALDH3B1;...
Aldosterone synthesis and secretion -1.73 2.06e-2 85/98 (86.73%) ATF2;CACNA1S;CREB1;...
Vibrio cholerae infection -1.74 1.92e-2 44/50 (88%) SEC61B;ADCY3;ATP6V1D;...
Inflammatory bowel disease -1.76 1.61e-2 58/65 (89.23%) STAT6;NFATC1;HLA-DPB1;...
Protein digestion and absorption -1.76 1.51e-2 78/103 (75.73%) COL1A1;COL6A2;COL11A2;...
Thyroid hormone synthesis -1.77 1.34e-2 66/75 (88%) ATP1B4;LRP2;ATF2;...
Ovarian steroidogenesis -1.79 9.55e-3 41/51 (80.39%) PRKACB;ADCY6;HSD3B2;...
Cocaine addiction -1.80 8.02e-3 42/49 (85.71%) GNAI3;ATF2;CREB1;...
Cortisol synthesis and secretion -1.81 8.44e-3 58/65 (89.23%) ATF2;CACNA1S;KCNK2;...
Metabolism of xenobiotics by cytochrome P450 -1.83 7.42e-3 49/77 (63.64%) ALDH3B1;ADH1A;ADH1C;...
TNF signaling pathway -1.84 6.29e-3 103/112 (91.96%) RELA;IRF1;IL18R1;...
Arachidonic acid metabolism -1.88 5.85e-3 48/61 (78.69%) HPGDS;GPX7;LTA4H;...
Cholesterol metabolism -1.89 6.24e-3 44/50 (88%) APOB;LIPG;LRP2;...
Phagosome -1.91 2.86e-3 118/152 (77.63%) SEC61B;CD14;ATP6V1D;...
Fat digestion and absorption -1.93 3.08e-3 35/43 (81.4%) PNLIPRP2;ACAT1;PLA2G2F;...
Legionellosis -1.95 3.34e-3 51/57 (89.47%) HBS1L;RELA;ARF1;...
Bile secretion -1.95 3.64e-3 68/90 (75.56%) SLCO1A2;SULT2A1;ADCY3;...
Retinol metabolism -1.97 4.01e-3 41/68 (60.29%) UGT2B4;AOX1;DGAT1;...
Steroid hormone biosynthesis -2.00 4.45e-3 43/61 (70.49%) UGT2B4;CYP7A1;CYP11B1;...
Epithelial cell signaling in Helicobacter pylori infect... -2.02 5.01e-3 62/70 (88.57%) JAM3;ATP6V1D;PTPN11;...
Rheumatoid arthritis -2.04 3.82e-3 78/93 (83.87%) CTSL;MMP3;CSF2;...
Amoebiasis -2.05 4.45e-3 99/102 (97.06%) PRKACB;RELA;PLCB1;...
Adrenergic signaling in cardiomyocytes -2.07 2.67e-3 130/150 (86.67%) GNAI3;PPP2CA;ATF2;...
Dilated cardiomyopathy -2.09 0.00e+0 86/96 (89.58%) ITGB3;SGCD;MYBPC3;...
Hypertrophic cardiomyopathy -2.10 0.00e+0 81/90 (90%) ITGB3;SGCD;PRKAA1;...
PPAR signaling pathway -2.22 0.00e+0 66/74 (89.19%) PPARG;MMP1;CYP7A1;...
Cardiac muscle contraction -2.31 0.00e+0 64/87 (73.56%) MYL4;CACNA1S;CACNG1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 10uM 6H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 15uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 10uM 6H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 10uM 6H
MDST8 CVCL_1400 Homo sapiens 10uM 6H
NCI-H508 CVCL_1561 Homo sapiens 10uM 6H
SNU-1040 CVCL_5001 Homo sapiens 10uM 6H
SNU-C4 CVCL_5008 Homo sapiens 10uM 6H
SNU-C5 CVCL_5009 Homo sapiens 10uM 6H
SW480 CVCL_0546 Homo sapiens 10uM 6H
SW620 CVCL_0547 Homo sapiens 10uM 6H
SW948 CVCL_0550 Homo sapiens 10uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 10uM 6H
HT115 CVCL_1294 Homo sapiens 10uM 6H
RKO CVCL_0504 Homo sapiens 10uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 10uM 6H
SNG-M CVCL_1707 Homo sapiens 10uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 10uM 6H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 1.25uM - 40uM 3H, 6H, 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 10uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 10uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 10uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 10uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 10uM 6H
T3M-10 CVCL_1729 Homo sapiens 10uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 10uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 10uM 6H
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 10uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 10uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 10uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 10uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 10uM 6H
OV7 CVCL_1623 Homo sapiens 10uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 10uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 10uM 6H
RMUG-S CVCL_1666 Homo sapiens 10uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 10uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 6H, 24H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 10uM 6H
PL-21 CVCL_2161 Homo sapiens 10uM 6H
SKM-1 CVCL_0010 Homo sapiens 10uM 6H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 10uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 10uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 10uM 6H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H