Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMIKFEL)

Drug Name
Levomepromazine Drug Info
Synonyms
METHOTRIMEPRAZINE; Nozinan; 60-99-1; Levoprome; Levomepromazina; Levomepromazinum; Levomepromazin; Nosinan; UNII-9G0LAW7ATQ; 2-Methoxytrimeprazine; Neozine; Levotomin; Minozinan; Milezin; 9G0LAW7ATQ; RP-7044; Levopromazioni; Veractil; Nomizan; Hirnamine; Dedoran; Nocinan; Nirnamine; CHEBI:6838; XP03; Methoxytrimeprazine; F-5116; Methotrimeprazine [USP]; Methotrimeprazine (USP); Bayer 1213; Arc-VI-C-5; CL 36467; CL 39743; Levomepromazinum [INN-Latin]; Levomepromazina [INN-Spanish]; EINECS 200-495-5; Methotrimeprazine
Cross-matching ID
PubChem CID
72287
ChEBI ID
CHEMBL1764
CAS Number
CAS 60-99-1
TTD Drug ID
D09LZT
VARIDT Drug ID
DR01271
INTEDE Drug ID
DR0942

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Complement and coagulation cascades 2.11 0.00e+0 76/85 (89.41%) TFPI;F5;SERPINA1;...
Histidine metabolism 2.09 0.00e+0 16/22 (72.73%) ALDH2;AOC1;MAOA;...
Retinol metabolism 2.09 0.00e+0 41/68 (60.29%) ALDH1A2;CYP3A5;UGT2B15;...
Ascorbate and aldarate metabolism 1.99 3.56e-3 15/30 (50%) ALDH2;UGT2B15;AKR1A1;...
Metabolism of xenobiotics by cytochrome P450 1.90 1.14e-2 49/77 (63.64%) GSTA1;CYP3A5;ALDH3A1;...
Phenylalanine metabolism 1.87 1.42e-2 14/17 (82.35%) MAOA;ALDH3A1;PAH;...
Drug metabolism 1.86 1.83e-2 78/151 (51.66%) DPYD;GSTA1;MAOA;...
Arginine and proline metabolism 1.85 1.78e-2 39/50 (78%) ALDH2;CKB;AOC1;...
Endocrine and other factor-regulated calcium reabsorpti... 1.82 2.53e-2 49/53 (92.45%) PLCB1;ESR1;PRKCA;...
Phospholipase D signaling pathway 1.80 2.42e-2 134/148 (90.54%) PDGFC;PLCB1;PRKCA;...
beta-Alanine metabolism 1.80 2.33e-2 25/30 (83.33%) ALDH2;DPYD;DPYS;...
Bile secretion 1.76 4.03e-2 68/90 (75.56%) GNAS;LDLR;KCNN2;...
Chagas disease 1.74 4.27e-2 93/102 (91.18%) TLR4;PLCB1;GNAS;...
Glycolysis / Gluconeogenesis 1.73 4.68e-2 56/67 (83.58%) ALDH2;FBP1;PKM;...
Pantothenate and CoA biosynthesis 1.73 4.36e-2 14/21 (66.67%) ALDH2;DPYD;DPYS;...
Adipocytokine signaling pathway 1.71 4.80e-2 64/69 (92.75%) ACSL4;ADIPOR2;ACSL1;...
Neutrophil extracellular trap formation 1.71 4.60e-2 101/189 (53.44%) TLR4;PLCB1;PRKCA;...
Valine, leucine and isoleucine degradation 1.69 4.90e-2 42/48 (87.5%) ALDH2;HMGCS1;BCAT2;...
Renin-angiotensin system 1.69 4.64e-2 20/23 (86.96%) ENPEP;ANPEP;AGTR1;...
Chemical carcinogenesis 1.68 4.98e-2 186/281 (66.19%) ESR1;GSTA1;PRKCA;...
Sphingolipid signaling pathway 1.68 4.81e-2 106/119 (89.08%) PLCB1;PRKCA;TP53;...
Arginine biosynthesis 1.67 4.85e-2 17/22 (77.27%) ASL;GLUD1;ARG1;...
Fatty acid degradation 1.67 4.70e-2 40/43 (93.02%) ALDH2;ACSL4;ACSL1;...
Graft-versus-host disease -1.71 4.44e-2 32/42 (76.19%) HLA-A;HLA-DOA;HLA-DOB;...
Allograft rejection -1.75 2.79e-2 32/38 (84.21%) HLA-A;HLA-DOA;HLA-DOB;...
Type I diabetes mellitus -1.76 3.13e-2 38/43 (88.37%) HLA-A;HLA-DOA;HLA-DOB;...
Autoimmune thyroid disease -1.85 3.66e-2 46/53 (86.79%) HLA-A;HLA-DOA;HLA-DOB;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H