Details of the Drug Pharmacogenomic Perturbation Atlas

TAK-875 Drug Info

TAK-875; Fasiglifam; 1000413-72-8; TAK875; TAK 875; UNII-GLP1W4JXAH; GLP1W4JXAH; (S)-2-(6-((2',6'-Dimethyl-4'-(3-(methylsulfonyl)propoxy)-[1,1'-biphenyl]-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid; CHEMBL1829174; [(3s)-6-({2',6'-Dimethyl-4'-[3-(Methylsulfonyl)propoxy]biphenyl-3-Yl}methoxy)-2,3-Dihydro-1-Benzofuran-3-Yl]acetic Acid; 3-Benzofuranacetic acid, 6-[[2',6'-diMethyl-4'-[3-(Methylsulfonyl)propoxy][1,1'-biphenyl]-3-yl]Methoxy]-2,3-dihydro-, (3S)-; J-501277

Cross-matching ID

PubChem CID

24857286

ChEBI ID

CHEMBL1829174

CAS Number

CAS 1000413-72-8

TTD Drug ID

D0V1WQ

INTEDE Drug ID

DR1882

General Information of Drug (ID: DMIM5AP)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Retinol metabolism	2.27	0.00e+0	41/68 (60.29%)	ALDH1A1;ADH1B;ALDH1A2;...
Staphylococcus aureus infection	2.14	0.00e+0	72/95 (75.79%)	C1S;KRT13;KRT19;...
Complement and coagulation cascades	2.09	0.00e+0	76/85 (89.41%)	C1S;C1R;CFH;...
DNA replication	2.01	0.00e+0	34/36 (94.44%)	PCNA;FEN1;POLE2;...
PPAR signaling pathway	1.99	0.00e+0	66/74 (89.19%)	SCD;FABP4;SORBS1;...
Metabolism of xenobiotics by cytochrome P450	1.98	0.00e+0	49/77 (63.64%)	HSD11B1;CYP1B1;ADH1B;...
Mismatch repair	1.97	0.00e+0	22/23 (95.65%)	PCNA;RFC3;MSH2;...
Histidine metabolism	1.97	9.59e-4	16/22 (72.73%)	ALDH3A1;HNMT;HDC;...
Drug metabolism	1.91	8.52e-4	78/151 (51.66%)	CES1;ADH1B;MPO;...
Tyrosine metabolism	1.83	6.90e-3	30/36 (83.33%)	ADH1B;TYRP1;ALDH3A1;...
Arginine and proline metabolism	1.75	1.88e-2	39/50 (78%)	ARG1;P4HA1;OAT;...
Glycolysis / Gluconeogenesis	1.74	1.92e-2	56/67 (83.58%)	HK2;ADH1B;ENO2;...
Asthma	1.74	1.83e-2	25/31 (80.65%)	FCER1A;PRG2;HLA-DRA;...
Pentose and glucuronate interconversions	1.67	3.45e-2	17/34 (50%)	SORD;DCXR;UGT2B4;...
Fructose and mannose metabolism	1.63	4.81e-2	30/33 (90.91%)	SORD;HK2;ALDOB;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.04uM - 10uM	24H

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.04uM - 10uM	24H

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H

Umbilical vein

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HUVEC-C	CVCL_2959	Homo sapiens	0.04uM - 10uM	24H