Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMIMJ8Z)

• Drug Name: SKF 38393 Drug Info
• Synonyms: SKF-38393; F-38393; 67287-49-4; F 38393; SKF38393; BRN 1543419; CHEMBL286080; 1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diol; 2,3,4,5-Tetrahydro-1-phenyl-1H-3-benzazepine-7,8-diol; 1H-3-Benzazepine-7,8-diol, 2,3,4,5-tetrahydro-1-phenyl-; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; SKF-38,393; SK-38393; C16H17NO2; 5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol; 1-Phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol
• Cross-matching ID:
  PubChem CID: 1242
  ChEBI ID: CHEMBL286080
  CAS Number: CAS 67287-49-4
  TTD Drug ID: D0OU7P

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Other glycan degradation	2.15	0.00e+0	13/18 (72.22%)	HEXB;HEXA;FUCA1;...
Oxidative phosphorylation	1.99	9.60e-3	93/133 (69.92%)	NDUFA4L2;ATP6V0E2;TCIRG1;...
Bile secretion	-1.75	4.98e-2	68/90 (75.56%)	ATP1A2;GNAS;AQP4;...
PPAR signaling pathway	-2.06	0.00e+0	66/74 (89.19%)	ANGPTL4;ACSBG1;NR1H3;...
Complement and coagulation cascades	-2.17	0.00e+0	76/85 (89.41%)	CD59;KLKB1;C4BPB;...
Steroid hormone biosynthesis	-2.17	0.00e+0	43/61 (70.49%)	AKR1C1;CYP11B2;CYP2E1;...
Retinol metabolism	-2.25	0.00e+0	41/68 (60.29%)	DGAT1;CYP2C8;CYP2C18;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲

Bone marrow

Neuroblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
SH-SY5Y	CVCL_0019	Homo sapiens	0.04uM - 10uM	24H	Hide ▲
SK-N-SH	CVCL_0531	Homo sapiens	0.04uM - 10uM	24H	Show ▼