Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMIOGZM)

Drug Name
ELIPRODIL Drug Info
Synonyms
Eliprodil; 119431-25-3; Eliprodil [INN]; C20H23ClFNO; SL 820715; SL 82-0715; CHEMBL28564; alpha-(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol; NCGC00092329-02; 1-Piperidineethanol, alpha-(4-chlorophenyl)-4-(4-fluorophenyl)-, (+-)-; DSSTox_RID_81089; DSSTox_CID_25744; DSSTox_GSID_45744; 1-(4-Chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethanol; (+-)-alpha-(p-Chlorophenyl)-4-(p-fluorobenzyl)-1-piperidineethanol; 1-(4-chlorophenyl)-2-[4-[(4-fluorophenyl)methyl]piperidin-1-yl]ethanol
Cross-matching ID
PubChem CID
60703
ChEBI ID
CHEMBL28564
CAS Number
CAS 119431-25-3
TTD Drug ID
D0S8CI

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome biogenesis in eukaryotes 1.99 1.26e-2 52/108 (48.15%) RPP38;REXO5;NXF3;...
Antigen processing and presentation 1.93 1.26e-2 60/78 (76.92%) HSPA1A;HSPA8;TAP1;...
Homologous recombination 1.82 1.68e-2 35/41 (85.37%) BRCA1;RAD54B;RAD51;...
Mismatch repair 1.81 1.42e-2 22/23 (95.65%) RFC5;PCNA;MSH6;...
DNA replication 1.75 2.26e-2 34/36 (94.44%) RFC5;PCNA;POLA2;...
Fanconi anemia pathway 1.71 3.88e-2 36/54 (66.67%) FANCI;BRCA1;RAD51;...
One carbon pool by folate 1.66 4.94e-2 15/20 (75%) TYMS;ATIC;DHFR;...
Central carbon metabolism in cancer 1.65 4.88e-2 67/70 (95.71%) LDHB;IDH2;FGFR1;...
Complement and coagulation cascades -1.70 4.60e-2 76/85 (89.41%) CFD;F10;CFHR4;...
Drug metabolism -1.72 3.69e-2 78/151 (51.66%) IMPDH1;GSTM3;TYMP;...
Renin-angiotensin system -1.73 3.08e-2 20/23 (86.96%) KLK2;ENPEP;CPA3;...
ECM-receptor interaction -1.76 2.49e-2 80/88 (90.91%) LAMB2;COL4A2;LAMB4;...
Steroid biosynthesis -1.80 2.19e-2 19/20 (95%) FDFT1;CYP27B1;SC5D;...
ABC transporters -1.82 1.98e-2 37/45 (82.22%) ABCD4;ABCA12;ABCD2;...
PPAR signaling pathway -1.85 1.71e-2 66/74 (89.19%) ACSL3;ACSL4;PCK2;...
Pentose and glucuronate interconversions -1.85 1.76e-2 17/34 (50%) UGT2A3;UGT2B4;GUSB;...
Primary bile acid biosynthesis -1.87 1.60e-2 15/17 (88.24%) HSD17B4;CYP7B1;AKR1D1;...
Bile secretion -2.04 0.00e+0 68/90 (75.56%) ATP1B2;ATP1B4;KCNN2;...
Metabolism of xenobiotics by cytochrome P450 -2.06 0.00e+0 49/77 (63.64%) GSTM3;CYP3A4;ALDH3A1;...
Retinol metabolism -2.09 0.00e+0 41/68 (60.29%) CYP3A4;RDH11;ADH6;...
Steroid hormone biosynthesis -2.11 0.00e+0 43/61 (70.49%) HSD11B1;UGT2A3;UGT2B4;...
Protein digestion and absorption -2.13 0.00e+0 78/103 (75.73%) COL4A2;ATP1B2;ATP1B4;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H